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The point spread function of a segmented aperture is seriously affected by the misalignment of the segments. Stringent requirements apply to position sensors and their calibration. The Active Phasing Experiment (APE) will be a technical instrument aimed at testing possible phasing techniques for a European Giant Optical Telescope (EGOT) in a representative(More)
A new adaptive optics system for the eye using a pyramid wavefront sensor interfaced in closed-loop with a piezoelectric deformable mirror is presented. Sensing parameters such as CCD integration time, pupil sampling and beam steering amplitude are tested on the bench and in vivo on several volunteers to optimize real-time optical correction. The system(More)
This paper addresses the application of observer-based control techniques for the adaptive optics system of the LBT telescope. In such a context, attention is focused on the use of Kalman and H ∞ filters to estimate the temporal evolution of phase perturbations due to the atmospheric turbulence and the telescope vibrations acting on tip/tilt modes. We shall(More)
This work describes a simple, sensitive and rapid liquid chromatography-high resolution mass spectrometry method for the quantitation of perhexiline and the simultaneous detection of perhexiline metabolites in C57bl/6 mice plasma. Only 5 μL of plasma was used for analysis. Pretreatment was limited to a 100-fold dilution ('dilute-and-shoot'). The analyte was(More)
We describe some novel technical approaches to implement multi-pyramid wavefront sensing, partially extendable to single pyramid and to any MCAO system. First we introduce an achromatic version of the pyramid, which allows for a much better spatial resolution on the pupil and also relaxes the specifications in term of turned edges. Then we discuss the(More)
We present a compact optical design for a multireference Shack-Hartmann-based wavefront sensor (WFS) for multiconjugate adaptive optical systems. The key component of this WFS design is a field lenslet array that separates the exit pupil images in the sensing plane for all reference sources. An analytical method for WFS optical design is presented, and the(More)
In drug discovery, there is increasing interest in peptides as therapeutic agents due to several appealing characteristics that are typical of this class of compounds, including high target affinity, excellent selectivity, and low toxicity. However, peptides usually present also some challenging ADME (absorption, distribution, metabolism, and excretion)(More)
Near InfraRed Spectroscopy (NIRS) is a potentially powerful tool for assessing the homogeneity of industrial powder blends. In the particular context of hospital manufacturing, we considered the introduction of the technique at a small pharmaceutical process scale, with the objective of following blend homogeneity in mixtures of seven components. This(More)