Simona Socrate

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Characterizing the dynamic mechanical properties of brain tissue is deemed important for developing a comprehensive knowledge of the mechanisms underlying brain injury. The results gathered to date on the tissue properties have been mostly obtained in vitro. Learning how these results might differ quantitatively from those encountered in vivo is a critical(More)
This study presents experimental results and computational analysis of the large strain dynamic behavior of single neurons in vitro with the objective of formulating a novel quantitative framework for the biomechanics of cortical neurons. Relying on the atomic force microscopy (AFM) technique, novel testing protocols are developed to enable the(More)
In this work we present an inverse finite-element modeling framework for constitutive modeling and parameter estimation of soft tissues using full-field volumetric deformation data obtained from 3D ultrasound. The finite-element model is coupled to full-field visual measurements by regularization springs attached at nodal locations. The free ends of the(More)
In this paper, we show that bone piezoelectricity-a phenomenon in which bone polarizes electrically in response to an applied mechanical stress and produces a short-range electric field-may be a source of intense blast-induced electric fields in the brain, with magnitudes and timescales comparable to fields with known neurological effects. We compute the(More)
We present a modular framework for mechanically regularized nonrigid image registration of 3D ultrasound and for identification of tissue mechanical parameters. Mechanically regularized deformation fields are computed from sparsely estimated local displacements. We enforce image-based local motion estimates by applying concentrated forces at mesh nodes of a(More)
Numerical techniques have been developed to evaluate local driving forces acting on material interfaces. Since migrations of the interfaces are associated with modifications of the microstructure, these methods can be applied to predict and model morphological evolution in multi-phase materials. Here this methodology has been applied to the study of an(More)
Constitutive models of the nonlinear, viscoelastic response of soft tissue under large strains typical of medical manipulations is required for accurate diagnostic and simulation purposes. We have modified a constitutive model used to describe cartilage and cervix to characterize the large strain mechanical behavior of breast tissue across pathologies(More)
Since the beginning of the military conflicts in Iraq and Afghanistan, there have been over 250,000 diagnoses of traumatic brain injury (TBI) in the U.S. military, with the majority of incidents caused by improvised explosive devices (IEDs). Despite the urgent need to understand blast-induced TBI in order to devise strategies for protection and treatment,(More)
We describe a modeling methodology intended as a preliminary step in the identification of appropriate constitutive frameworks for the time-dependent response of biological tissues. The modeling approach comprises a customizable rheological network of viscous and elastic elements governed by user-defined 1D constitutive relationships. The model parameters(More)
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract This study presents experimental results and computational analysis of the large strain dynamic behavior of single neurons in vitro with the objective of formulating a novel quantitative framework for the biomechanics of cortical(More)