Simona Paraschiv

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SUMMARY RegaDB is a free and open source data management and analysis environment for infectious diseases. RegaDB allows clinicians to store, manage and analyse patient data, including viral genetic sequences. Moreover, RegaDB provides researchers with a mechanism to collect data in a uniform format and offers them a canvas to make newly developed(More)
HIV-1 subtype B is predominant in Europe except in some countries from Eastern Europe which are characterized by a high prevalence of non-B subtypes and circulating recombinant forms (CRFs). Romania is a particular case: the HIV-1 epidemic started with subtype F1 which is still the most prevalent. Previous studies have shown an increasing prevalence of(More)
  • Pieter Libin, Gertjan Beheydt, Koen Deforche, Stijn Imbrechts, Fossie Ferreira, Kristel Laethem +62 others
  • 2016
permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Summary: RegaDB is a free and open source data management and analysis environment for infectious diseases. RegaDB allows clinicians to store, manage and analyze patient data, including viral genetic sequences. Moreover, RegaDB(More)
Session title: epidemiology, subtypes, regional issues O1 HIV-1 diversity in Bulgaria (current molecular epidemiological picture) Objectives In Bulgaria 1606 cases with HIV/AIDS were diagnosed from 1986 until 2012. Epidemiological data indicated greater heterogeneity of HIV-1 positive population, including minority groups, migrants, and recent increase of(More)
BACKGROUND Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial regimen. In addition to optimizing individual patient management, these baseline resistance data enable transmitted drug resistance (TDR) to(More)
Since 2011 Romania is experiencing a dramatic increase of newly diagnosed HIV infections among injecting drug users (IDUs), mainly linked to the introduction of new psychoactive substances (NPS) on the Romanian market, their use being related to higher levels of risk behavior compared to opioid abuse. There is no sufficient data showing the natural course(More)
Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) co-infect five million people worldwide. HIV-HCV co-infection represents the major cause of liver related morbidity among the HIV infected patients. The current HCV standard of care consisting of pegy-lated a-interferon and ribavirin has variable efficacy and considerable side-effects. A major(More)
Objective: to estimate the rate and the significance of low level viraemia in HIV positive patients registered in the National Institute for Infectious Diseases " Prof. Dr. Matei Balş " , Bucharest, Romania. We retrospectively analysed the rate of HIV viral loads (VL) <200 copies/mL in patients admitted in our institute from 2011 to 2013. The patients with(More)
Cryptococcosis represents a major life-threatening fungal infection in patients with severe HIV infection. Crypto-coccal meningoencephalitis is the most common manifestation of cryptococcosis in patients with advanced immunosuppression. Objectives: evaluating risk factors for severe evolution of patients with HIV infection and meningitis. Possible risk(More)