Simona Gasbarri

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Starting from commercially available N-protected l-α-amino acids, N,N′-protected gem-diaminic units were obtained by a two-step methodology. A Hofmann reaction performed using a primary alcohol as the solvent to trap the isocyanate intermediate represents the key step of the new synthetic procedure. Then, the methodology was applied to α-carbamoyl(More)
Non-symmetric disubstituted malonamides rAA-mGly-AA′, obtained from Meldrum’s acid, were considered as methylene active compounds and a Knoevenagel condensation methodology was developed involving piperidine and activated 4 Å molecular sieves as catalysts. The reaction is efficient, broad in scope, and easy to perform and allows access to E/Z mixtures of(More)
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