Simona Botea

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Starting from the existence of some autoimmune diseases (i.e. bronchial asthma or miastenia gravis) we asked ourselves if some plasmatic factors do exist, influencing the receptor--mediator relations in cardiovascular system during some illnesses having unknown etiology, as arterial hypertension. For this reason, in this work was tested the hypothesis that,(More)
Endogenous and exogenous Na-glutamate (Glu) accumulation in central nervous system (CNS) may be involved in neuronal death, leading to neurodegenerative disorders in humans. This paper describes the effect of in vivo and in vitro Glu treatment on rat bioelectric activity in hypothalamus (HT) and cerebral cortex (C), as well as the measurement of brain(More)
Arterial hypertension, including the elucidation of hypertension pathogenic mechanisms involving elements in the composition of the blood, continues to represent a topical research area. Recent work, such as nuclear magnetic resonance studies looking into red cell permeability, illustrates the presence of modifications of red cell permeability to water(More)
OBJECTIVE To compare the efficacy of a simple irradiation scheme with that of a double-fractionated irradiation scheme on the healing of rat skin lesions using in vivo monitoring of tissue diffuse reflectance. BACKGROUND DATA Low-level laser therapy (LLLT) is used in medicine for treating a wide range of pathological conditions. The practical benefits of(More)
An oxidative insult can induce severe damage, as in the phenomenon of myocardial ischemia and reperfusion. However, there are situations in which the damage is not so obvious (e.g., silent ischemia or aging), and the negative effects will be seen only in time. Our aim was to reveal these small changes in the myofilaments by using the nuclear magnetic(More)
The nuclear hepatocytic chromatin showed to be sensitive to the harmful effects of thioacetamide (TAA) and benzo(a)pyrene (BP), a hepatic and a nonhepatic carcinogen. Intrinsic viscosity is a reliable indicator of the drug-induced chromatin changes. A single dose of TAA induced a reversible alteration of viscosity, but the same kind of treatment using BP(More)
The present study was carried out on the uptake of 125I-insulin in the tissues or organs (liver, subcutaneous adipose tissue, striated muscle, renal cortex, frontal lobes of the brain) of normal Wistar rats or from animals treated with benzo(a)pyrene, a powerful carcinogen which s metabolically activated in the liver. The carcinogen was administered as(More)
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