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Transient receptor potential channels: targeting pain at the source
Pain results from the complex processing of neural signals at different levels of the central nervous system, with each signal potentially offering multiple opportunities for pharmacologicalExpand
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Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons
We have cloned a second tetrodotoxin-resistant (TTX-R) sodium channel α subunit, SNS2, with the same amino-acid sequence as a putative sodium channel α subunit NaN (ref. 1). SNS2 expression inExpand
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The Voltage-Gated Sodium Channel Nav1.9 Is an Effector of Peripheral Inflammatory Pain Hypersensitivity
We used a mouse with deletion of exons 4, 5, and 6 of the SCN11A (sodium channel, voltage-gated, type XI, α) gene that encodes the voltage-gated sodium channel Nav1.9 to assess its contribution toExpand
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The pattern of expression of the voltage-gated sodium channels Nav1.8 and Nav1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models
&NA; A spared nerve injury of the sciatic nerve (SNI) or a segmental lesion of the L5 and L6 spinal nerves (SNL) lead to behavioral signs of neuropathic pain in the territory innervated by adjacentExpand
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Differential expression of tetrodotoxin-resistant sodium channels Nav1.8 and Nav1.9 in normal and inflamed rats
In an attempt to understand mechanisms underlying peripheral sensitization of primary afferent fibers, we investigated the presence of the tetrodotoxin-resistant Na+ channel subunits Nav1.8 (SNS) andExpand
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Multiple mechanisms have been tested in pain--how can we improve the chances of success?
Recent advances in understanding the pathophysiology of pain have led to a wealth of molecular targets for novel analgesic drugs and many clinical drug trials. There have been successes, like theExpand
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Please mind the gap: students' perspectives of the transition in academic skills between A-level and degree-level geography
This paper explores first-year undergraduates' perceptions of the transition from studying geography at pre-university level to studying for a degree. This move is the largest step students make inExpand
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Improving the transition to university: introducing student voices into the formal induction process for new geography undergraduates
Recently, there has been renewed interest in the area of school to university transitions within geography. This article focuses upon one aspect of these transitions, namely the induction programmesExpand
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Nerve Fibers in Lumbar Spine Structures and Injured Spinal Roots Express the Sensory Neuron–Specific Sodium Channels SNS/PN3 and NaN/SNS2
Study Design. This prospective study examined the innervation of lumbar spine in tissues from patients with lower back pain and spine nerve roots from patients with traumatic brachial plexusExpand
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