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There are persistent concerns about the influence of the pharmaceutical and device industries on the medical literature, and particularly on the reporting of clinical trials, which can include the distortion of the true evidence base of medical interventions and overestimation of the clinical benefit of a drug used to treat patients [1]. An especially(More)
BACKGROUND Treatment of chronic urticaria is challenging because many patients are refractory to or experience adverse effects with conventional therapy. Recently, short-term efficacy of omalizumab has been demonstrated. OBJECTIVE To determine both the short- and long-term efficacy of omalizumab in the treatment of chronic urticaria. METHODS Sixteen(More)
BACKGROUND Evidence has shown that omalizumab, a subcutaneous anti-IgE monoclonal antibody, is highly effective for the treatment of chronic urticaria. OBJECTIVE To evaluate omalizumab 150 mg/month in severe, difficult-to-treat, chronic urticaria in a real-life setting. METHODS This prospective open-label study evaluated of 150 mg of omalizumab in(More)
Spiritualism was one of the most salient cultural phenomena of late-nineteenthcentury American life. The belief of considerable numbers of respectable citizens that they could communicate with the dead via an entranced medium called into question both popular and scientific conceptions of rationality, volition, and freedom. In turn, these changing ideas(More)
True-crime stories of outlaws have been a part of popular culture in England since the Middle Ages. Tales of criminality gained increasing circulation in print through the Old Bailey Sessions Papers (1674–1913) and the “dying confessions” published in broadside form by the Ordinary of Newgate in the eighteenth century.1 The confessional broadsides were(More)
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