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antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
Abstract Secondary metabolites produced by bacteria and fungi are an important source of antimicrobials and other bioactive compounds. In recent years, genome mining has seen broad applications inExpand
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MIBiG 2.0: a repository for biosynthetic gene clusters of known function
Abstract Fueled by the explosion of (meta)genomic data, genome mining of specialized metabolites has become a major technology for drug discovery and studying microbiome ecology. In these efforts,Expand
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Sequence-based classification of type II polyketide synthase biosynthetic gene clusters for antiSMASH
The software antiSMASH examines microbial genome data to identify and analyze biosynthetic gene clusters for a wide range of natural products. So far, type II polyketide synthase (PKS) gene clustersExpand
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BiG-FAM: the biosynthetic gene cluster families database
Abstract Computational analysis of biosynthetic gene clusters (BGCs) has revolutionized natural product discovery by enabling the rapid investigation of secondary metabolic potential within microbialExpand
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Designing sgRNAs for CRISPR-BEST base editing applications with CRISPy-web 2.0
TLDR
We present an updated version of the interactive CRISPy-web single guide RNA design tool https://crispy.secondarymetabolites.org/ that was built to support “classical” CRISPR and now alsoCRISPR-BEST workflows. Expand
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The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes
Abstract Microorganisms produce natural products that are frequently used in the development of antibacterial, antiviral, and anticancer drugs, pesticides, herbicides, or fungicides. In recent years,Expand
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