Simon P. Aiken

Learn More
1. Linopirdine (DuP 996) has been shown to enhance depolarization-induced release of several neurotransmitters in the CNS through a mechanism which may involve K+ channel blockade. The electrophysiological effects of linopirdine were therefore investigated directly, by use of conventional voltage recording and single electrode voltage-clamp. 2. Linopirdine(More)
The central pattern generator for swimming Xenopus embryo is organized as two half-centres linked by reciprocal inhibition. Microelectrode recordings suggest that Xenopus neurons are poorly excitable, necessitating a key role for postinhibitory rebound in the operation of the central pattern generator. However the Xenopus central pattern generator seems(More)
Synaptic transmission, and its sensitivity to the effects of 3,4-diaminopyridine (3,4-DAP) and the phosphatase 2,3-butanedione monoxime (BDM), was examined for “crushed fiber” preparations of rat extensor digitorum longus muscle undergoing reinnervation after nerve crush. While mean quantal content (m) of endplate potentials (EPPs) was low early during(More)
The neuromuscular effects of a peptide toxin (peptide I) from venom of Trimeresurus wagleri were investigated using the rat extensor digitorum longus muscle/peroneal nerve preparation. Sub-micromolar concentrations depressed endplate currents (EPCs) produced in response to nerve stimulation. Since quantal content of EPCs was not altered, it appears that the(More)
Histidine has been reported to affect body zinc status by increasing urinary zinc excretion. The effects of experimental histidinemia on distribution of65Zn in anesthetized rats were studied. Infusion ofl-histidine at a rate sufficient to raise plasma concentrations to approximately 2mm for 6h starting 48 h after a single intraperitoneal65Zn injection did(More)
The objective of this study was to further investigate neurochemicals which might modulate congenital differences in sensitivity to the acute and chronic effects of ethanol. Catecholamine levels were measured in the cortex, hippocampus, midbrain and cerebellum of long-sleep (LS) and short-sleep (SS) mice. These measurements revealed that norepinephrine (NE)(More)
While investigating the decline in resting membrane potential (RMP) of rat skeletal muscle fibers in zero potassium solution, we discovered that there is seasonal variation in the response of the extensor digitorum longus muscle (EDL). In January, most EDL fibers hyperpolarize in zero K+; in September, most depolarize; the distribution of RMPs recorded in(More)
The time constant of the decay (tau) of miniature end-plate currents (MEPCs) recorded from muscles excised from long-sleep (LS) and short-sleep (SS) mice was measured as an indicator of the mean open time of the channel which is gated by the nicotinic acetylcholine receptor. Similar tau values were recorded from LS and SS mice, and these values were(More)
  • 1