Simon McDonald

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Historically, one of the key problems in neglected disease drug discovery has been identifying new and interesting chemotypes. Phenotypic screening of the malaria parasite, Plasmodium falciparum has yielded almost 30,000 submicromolar hits in recent years. To make this collection more accessible, a collection of 400 chemotypes has been assembled, termed the(More)
Evolving Takagi Sugeno (eTS) models are optimised for use in applications with high sampling rates. This mode of use produces excellent prediction results very quickly and with low memory requirements, even with large numbers of input attributes. In this paper eTS modelling is adapted for optimality in situations where memory usage and processing time are(More)
Researchers attempting to integrate socio-economic data in watershed planning often draw on nationally collected census data. However, there are critical limitations to the usefulness of this type of data for decision makers operating at the watershed scale. In this paper we demonstrate the relevance of spatially referenced socio-economic data collected(More)
Three types of data modelling technique are applied retrospectively to individual patients' anticoagulation therapy data to predict their future levels of anticoagulation. The results of the different models are compared and discussed relative to each other and previous similar studies. The conclusions of earlier papers, that machine learning could help(More)
Predicting species distributions with changing climate has often relied on climatic variables, but increasingly there is recognition that disturbance regimes should also be included in distribution models. We examined how changes in rainfall and disturbances along climatic gradients determined demographic patterns in a widespread and long-lived tree(More)
Biodiversity in Australia continues to decline despite substantial government efforts to promote conservation. A statutory duty of care for biodiversity could promote positive outcomes and complement existing regulatory and voluntary approaches. Interest in a duty of care has been persistent, but progress elusive. Two interrelated issues around the social(More)
The objectives of this work in progress are to improve the levels of care in anticoagulation therapy while reducing the effort required and the costs. This will be achieved by the preprocessing of the available real world data and projecting it into a suitable analysis space before modelling with individualised, constantly learning Evolving Takagi Sugeno(More)
The speech-language pathology workforce strives to provide equitable, quality services to multilingual people. However, the extent to which this is being achieved is unknown. Participants in this study were 2849 members of Speech Pathology Australia and 4386 children in the Birth cohort of the Longitudinal Study of Australian Children (LSAC). Statistical(More)
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