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Historically, one of the key problems in neglected disease drug discovery has been identifying new and interesting chemotypes. Phenotypic screening of the malaria parasite, Plasmodium falciparum has yielded almost 30,000 submicromolar hits in recent years. To make this collection more accessible, a collection of 400 chemotypes has been assembled, termed the(More)
Heart rate is dependent on a cycle of depolarization and repolarization of the atria and ventricles that is regulated by intrinsic and extrinsic factors. Inhomogeneity in ventricular repolarization, measured as QT interval dispersion (QTd) is likely to lead to arrhythmia. The role of the autonomic nervous system in the development of this inhomogeneity is(More)
Evolving Takagi Sugeno (eTS) models are optimised for use in applications with high sampling rates. This mode of use produces excellent prediction results very quickly and with low memory requirements, even with large numbers of input attributes. In this paper eTS modelling is adapted for optimality in situations where memory usage and processing time are(More)
Predicting species distributions with changing climate has often relied on climatic variables, but increasingly there is recognition that disturbance regimes should also be included in distribution models. We examined how changes in rainfall and disturbances along climatic gradients determined demographic patterns in a widespread and long-lived tree(More)
Three types of data modelling technique are applied retrospectively to individual patients' anticoagulation therapy data to predict their future levels of anticoagulation. The results of the different models are compared and discussed relative to each other and previous similar studies. The conclusions of earlier papers, that machine learning could help(More)
Improving risk assessment to provide evidence for preventative intervention has recently become more of a focus in cardiovascular medicine with atherosclerosis as an early manifestation of cardiovascular disease. The total cholesterol to high-density lipoprotein (TC/HDL) ratio is often used an atherogenic index. High levels of the TC/HDL ratio also affect(More)
The Goulburn Broken Catchment Management Authority (GB CMA) contracted Charles Sturt University’s Institute for Land, Water and Society (ILWS) to explore landholder and wider community values, perceptions, priorities and actions in relation to management of the riparian zone of the Mid-Goulburn River. This research was intended to support the implementation(More)
Researchers attempting to integrate socio-economic data in watershed planning often draw on nationally collected census data. However, there are critical limitations to the usefulness of this type of data for decision makers operating at the watershed scale. In this paper we demonstrate the relevance of spatially referenced socio-economic data collected(More)
The objectives of this work in progress are to improve the levels of care in anticoagulation therapy while reducing the effort required and the costs. This will be achieved by the preprocessing of the available real world data and projecting it into a suitable analysis space before modelling with individualised, constantly learning Evolving Takagi Sugeno(More)