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Pseudorehearsal is a mechanism proposed by Robins which alleviates catastrophic forgetting in multi-layer perceptron networks. In this paper, we extend the exploration of pseudo-rehearsal to a Hop® eld-type net. The same general principles apply: old information can be rehearsed if it is available, and if it is not available, then generating and rehearsing(More)
The "baby machine" provides a means of generating synchronized cultures of minimally perturbed cells. We describe the use of this technique to establish the key cell-cycle parameters of hyperthermophilic archaea of the genus Sulfolobus. The 3 DNA replication origins of Sulfolobus acidocaldarius were mapped by 2D gel analysis to near 0 (oriC2), 579 (oriC1),(More)
We suggest that any brain-like (artificial neural network based) learning system will need a sleep-like mechanism for consolidating newly learned information if it wishes to cope with the sequential / ongoing learning of significantly new information. We summarise and explore two possible candidates for a computational account of this consolidation process(More)
Although the Archaea exhibit an intriguing combination of bacterial- and eukaryotic-like features, it is not known how these prokaryotic cells segregate their chromosomes before the process of cell division. In the course of our analysis of the third replication origin in the archaeon Sulfolobus solfataricus, we identify and characterise sister chromatid(More)
Serious games find wide application in the health domain, occupying their own place in the video game industry (games for health). Currently, there is a proliferation of cognitive training, exercise and social games, targeting one of the most dangerous disease of the era: demen-tia, as well as its various symptoms and stages like Mild Cognitive Impairment(More)
Educational games constitute a major field inside the serious games ecosystem, attempting to educate the players, while entertaining them. Augmented Reality (AR) has found application in educational games, introducing properties that improve gameplay and that potentially produce unique educational affordances. In this study, we present the " Table Mystery "(More)
Computer games are no longer just a trivial activity played by children in arcades. Social networking and casual gaming have broadened the market for, and acceptance of, games. This has coincided with a realization of their power to engage and motivate players. Good computer games are excellent examples of modern educational theory [1]. The military, health(More)
The EcoRV restriction endonuclease normally shows a high specificity for its recognition site on DNA, GATATC. In standard reactions, it cleaves DNA at this site several orders of magnitude more readily than at any alternative sequence. But in the presence of dimethyl sulphoxide and at high pH, the EcoRV enzyme cleaves DNA at several sites that differ from(More)
Hopfield/constraint satisfaction type networks can be used to learn (autoassociate) patterns. Random inputs to the network will sometimes converge on states which are learned patterns, and sometimes converge on states which are unlearned/spurious. It would be useful for many reasons to be able to tell whether or not a given state was learned or spurious. In(More)