Simon Krige

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The study consisted of two parts: 1. The standard system in use at our hospital for gas delivery under the drapes during eye surgery under local anaesthesia was compared with one incorporating a venturi. 2. The oxygen concentration at the operation site was measured with three methods of draping using the two systems. Twenty-three patients and thirty-one(More)
A prospective double-blind study was conducted to compare the anti-emetic efficacy of ondansetron and droperidol in preventing postoperative emesis following strabismus surgery. A sample size of 213 patients was divided into three equal groups to receive ondansetron 150 micrograms/kg (Group A), ondansetron 75 micrograms/kg (Group B), or droperidol 75(More)
Four hundred and eight consecutive patients scheduled for cataract surgery under local anaesthesia were randomly allocated to one of two types of regional anaesthesia. One group was given the standard retrobulbar block combined with a facial nerve block of the O'Brien type, and the second group was given a modified peribulbar block. Results indicate that it(More)
The use of virtual screening to find new drug hits and leads has become commonplace within the pharmaceutical industry. 2D methods have largely been replaced by 3D ligand-based methods and by structure-based methods (docking) where a reliable protein structure is available. However, the computational cost of calculating 3D molecular similarities is much(More)
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