Simon K. W. Lam

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The pre-sensor 1 (PS1) hairpin is found in ring-shaped helicases of the AAA+ family (ATPases associated with a variety of cellular activities) of proteins and is implicated in DNA translocation during DNA unwinding of archaeal mini-chromosome maintenance (MCM) and superfamily 3 viral replicative helicases. To determine whether the PS1 hairpin is required(More)
ZNF403, also known as GGNBP2 (gametogenetin binding protein 2), is a highly conserved gene implicated in spermatogenesis. However, the exact biological function of ZNF403 is not clear. In this study, we identified the role of ZNF403 in cell proliferation and cell-cycle regulation by utilizing short hairpin RNA (shRNA)-mediated knockdown. ZNF403-specific(More)
BACKGROUND Genetic mutations in several ubiquitously expressed RNA splicing genes such as PRPF3, PRP31 and PRPC8, have been found to cause retina-specific diseases in humans. To understand this intriguing phenomenon, most studies have been focused on testing two major hypotheses. One hypothesis assumes that these mutations interrupt retina-specific(More)
BACKGROUND Vertebrate trunk induction requires inhibition of bone morphogenetic protein (BMP) signaling, whereas vertebrate head induction requires concerted inhibition of both Wnt and BMP signaling. RNA binding proteins play diverse roles in embryonic development and their roles in vertebrate head development remain to be elucidated. RESULTS We first(More)
Delay Tolerant Networking has been a hot topic of interest in networking since the start of the century, and has sparked a significant amount of research in the area, particularly in an age where the ultimate goal is to provide ubiquitous con-nectivity, even in regions previously considered inaccessible. Protocols and applications in popular use on the(More)
This study describes the successful delivery of helper-dependent adenoviral vectors to the mouse retina with long term and robust levels of reporter expression in the retina without apparent adverse effects. Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated(More)
It is with a proud sense of accomplishment that I am sharing with you this last Editorial during my tenure as your Editor-in-Chief. Since January 1, 2007, I have had the honor and privilege of serving as APJM's first Editor-in-Chief who is based outside of Asia. Now, after nearly three years and hundreds of manuscripts, I am pleased to announce my editorial(More)