Simon Jonathan Tuke

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  • Yuen H. Kwok, Jonathan Tuke, Lauren L. Nicotra, Peter M. Grace, Paul E. Rolan, Mark R. Hutchinson
  • 2013
BACKGROUND Chronic pain patients have increased peripheral blood mononuclear cell Interkeukin-1β production following TLR2 and TLR4 simulation. Here we have used a human-to-rat and rat-to-human approach to further investigate whether peripheral blood immune responses to TLR agonists might be suitable for development as possible systems biomarkers of chronic(More)
Study of the Internet's high-level structure has for some time intrigued scientists. The AS-graph (showing interconnections between Autonomous Systems) has been measured, studied, modelled and discussed in many papers over the last decade. However, the quality of the measurement data has always been in question. It is by now well known that most(More)
How can researchers test for heterogeneity in the local structure of a network? In this paper, we present a framework that utilizes random sampling to give subgraphs which are then used in a goodness of fit test to test for heterogeneity. We illustrate how to use the goodness of fit test for an analytically derived distribution as well as an empirical(More)
Translating promising preclinical drug discoveries to successful clinical trials remains a significant hurdle in pain research. Although animal models have significantly contributed to understanding chronic pain pathophysiology, the majority of research has focused on male rodents using testing procedures that produce sex difference data that do not align(More)
The controlled release of diflunisal and fluconazole from tablets made of novel polymers, poly(acrylic acid) (PAA) crosslinked with either β-cyclodextrin (βCD) or hydroxypropyl-βCD (HPβCD), was investigated and Carbopol 934P (Carbopol) was used as a highly crosslinked PAA for comparison. Diflunisal strongly associates with βCD-PAA and HPβCD-PAA polymers (K(More)
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