Simon J R Gibbs

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Motor-evoked potentials (MEPs) from forearm muscles were recorded in response to single-shock electrical stimulation of motor cortex of rats (n = 15) under pentobarbital anesthesia and controlled room air ventilation. In addition, electroencephalograms (EEGs) were recorded for all animals. Following baseline MEP recording in room air (21% O2), animals were(More)
RATIONALE The bone morphogenetic receptor type II gene is the major genetic determinant for the inherited form of pulmonary arterial hypertension. However, deleterious mutations of this gene are not observed in the majority of subjects who develop the condition spontaneously and familial disease displays age- and sex-dependent penetrance, indicating the(More)
UNLABELLED Pulmonary hypertension (PH) is a progressive disease with a poor prognosis. Identifying chronic thromboembolic pulmonary disease as a cause of PH has major clinical implications as these patients could be potentially offered a surgical cure. Ventilation-perfusion (V/Q) scintigraphy has a high sensitivity to detect embolic disease but its value(More)
An extensive review of published articles on the subject of endoscopic carpal tunnel release surgery is presented, encompassing six endoscopic techniques used to treat carpal tunnel syndrome. Since the first report in 1987, 7091 patients have undergone 8068 operations. The overall success rate has been 96.52%, with a complication rate of 2.67% and a failure(More)
Spasmodic dysphonia is a focal laryngeal dystonia. Laryngeal dystonia presents as: adductor spasmodic dysphonia with the characteristic strain-strangle voice; abductor spasmodic dysphonia with hypophonia and breathy breaks in connected speech; and adductor respiratory dystonia with paradoxical vocal fold motion and intermittent stridor. Current treatment(More)
Cortical somatosensory evoked potential (CSEP), spinal somatosensory evoked potential (SSEP), and electroencephalogram were recorded in rats under pentobarbital anesthesia. After baseline recordings in room air (21% O2), animals were subjected to a graded hypoxia at 15.75%, 10.5%, and 5.25% oxygen levels for 10 minutes. Each level of hypoxia was followed by(More)
Rationale: The bone morphogenetic receptor type II gene is the major genetic determinant for the inherited form of pulmonary arterial hypertension. However, deleterious mutations of this gene are not observed in the majority of subjects who develop the condition spontaneously and familial disease displays age-and sex-dependent penetrance indicating the(More)
We have developed a balloon device that creates reproducible graded compression of the rat spinal cord. It uses a modified Camino intracranial pressure monitor bolt with a small latex balloon attached to the tip. The device is affixed to the spinous processes of two cervicothoracic vertebrae and positioned directly over an exposed segment of spinal cord.(More)
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