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The function of the profuse descending innervation from the auditory cortex is largely unknown; however, recent studies have demonstrated that focal stimulation of auditory cortex effects frequency tuning curves, duration tuning, and other auditory parameters in the inferior colliculus. Here we demonstrate that, in an anesthetized guinea pig, nonfocal(More)
Reversible inactivation of the cortex by surface cooling is a powerful method for studying the function of a particular area. Implanted cooling cryoloops have been used to study the role of individual cortical areas in auditory processing of awake-behaving cats. Cryoloops have also been used in rodents for reversible inactivation of the cortex, but recently(More)
The separation of concurrently presented sounds into distinct auditory objects is accompanied by the elicitation of the object-related negativity (ORN) component of the event-related potential (ERP). In the present study, participants were exposed to tone sequences containing not only concurrent (harmonicity), but also sequential cues (similarity to(More)
Previous experiments have described highly specific effects of noradrenergic agonists on synaptic transmission in the dentate gyrus (DG). For example, perfusion of hippocampal slices with the beta-noradrenergic agonist isoproterenol induces a long-lasting potentiation (LLP) of extracellularly recorded responses following stimulation of the medial perforant(More)
We report on the design and the collection of a multi-modal data corpus for cognitive acoustic scene analysis. Sounds are generated by stationary and moving sources (people), that is by omni-directional speakers mounted on people's heads. One or two subjects walk along predetermined systematic and random paths, in synchrony and out of sync. Sound is(More)
The function of the profuse descending innervation from the auditory cortex is largely unknown; however recent studies have demonstrated that focal stimulation of auditory cortex effects frequency tuning curves, duration tuning and other auditory parameters in the inferior colliculus. Here we demonstrate that, in an anesthetized guinea pig, non-focal(More)
Objectives: To determine whether the process responsible for the mismatch negativity (MMN) might be involved in the analysis of temporal sound patterns for information. Methods: Synthesized musical instrument tones of 'clarinet' timbre were delivered in a continuous sequence at 16 tones/s, such that there was virtually no N1 potential to each individual(More)
To test an artificial surfactant in vivo, six 120-d gestational age lambs were treated at birth with a mixture of a 9:1 M ratio of [14C]dipalmitoyl phosphatidylcholine (DPC) and phosphatidylglycerol at a dose of 100 mg DPC/kg. Nine other lambs were not treated. The mean PO2 values of the lambs treated with artificial surfactant were 65.7 +/- 11 mm Hg vs.(More)
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