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- Katie J Ewer, Geraldine A. O’Hara, +24 authors Adrian V S Hill
- Nature communications
- 2013
Induction of antigen-specific CD8(+) T cells offers the prospect of immunization against many infectious diseases, but no subunit vaccine has induced CD8(+) T cells that correlate with efficacy in… (More)
- Simon J Draper, Anne C Moore, +5 authors Adrian V S Hill
- Nature Medicine
- 2008
Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus–poxvirus prime-boost immunization regime… (More)
- Susanne Helena Hodgson, Elizabeth A. Juma, +32 authors Kevin Marsh
- Front. Microbiol.
- 2014
BACKGROUND
Controlled human malaria infection (CHMI) studies are a vital tool to accelerate vaccine and drug development. As CHMI trials are performed in a controlled environment, they allow… (More)
- Jagadeesh Bayry, Elma Tchilian, +8 authors David F. Tough
- Proceedings of the National Academy of Sciences…
- 2008
Adjuvants are substances that enhance immune responses and thus improve the efficacy of vaccination. Few adjuvants are available for use in humans, and the one that is most commonly used (alum) often… (More)
- Thein Z Win, Simon J Draper, Rebecca L Read, James W. Pearce, Chris J. Norbury, S. W. Wang
- Molecular and cellular biology
- 2006
Polyadenylation in eukaryotes is conventionally associated with increased nuclear export, translation, and stability of mRNAs. In contrast, recent studies suggest that the Trf4 and Trf5 proteins,… (More)
- Alexander D Douglas, Andrew R Williams, +13 authors Simon J Draper
- Nature communications
- 2011
Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are mostly focused on well-studied merozoite antigens that induce immune responses after natural exposure, but have… (More)
- Susanne Helena Sheehy, Christopher J. A. Duncan, +29 authors Simon J Draper
- Molecular therapy : the journal of the American…
- 2012
The induction of cellular immunity, in conjunction with antibodies, may be essential for vaccines to protect against blood-stage infection with the human malaria parasite Plasmodium falciparum. We… (More)
- Susanne Helena Sheehy, Christopher J. A. Duncan, +20 authors Simon J Draper
- Molecular therapy : the journal of the American…
- 2011
Efficacy trials of antibody-inducing protein-in-adjuvant vaccines targeting the blood-stage Plasmodium falciparum malaria parasite have so far shown disappointing results. The induction of… (More)
- Simon J Draper, Sumi Biswas, +10 authors Adrian V S Hill
- Journal of immunology
- 2010
Protein-in-adjuvant formulations and viral-vectored vaccines encoding blood-stage malaria Ags have shown efficacy in rodent malaria models and in vitro assays against Plasmodium falciparum. Abs and… (More)
- Christopher J. A. Duncan, Susanne Helena Sheehy, +25 authors Ruth D. Ellis
- PloS one
- 2011
BACKGROUND
Inhibition of parasite growth is a major objective of blood-stage malaria vaccines. The in vitro assay of parasite growth inhibitory activity (GIA) is widely used as a surrogate marker for… (More)