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The snake-in-the-box problem is concerned with finding a longest induced path in a hypercube Qn. Similarly, the coil-in-the-box problem is concerned with finding a longest induced cycle in Qn. We consider a generalization of these problems that considers paths and cycles where each pair of vertices at distance at least k in the path or cycle are also at(More)
Foamy viruses are non-pathogenic in vivo and naturally infect all species of non-human primates (NHP). Simian foamy viruses (SFV) are highly prevalent in both free ranging and captive NHP but few longitudinal studies have been performed to assess the prevalence and biodistribution of SFV within captive NHP. LTR and pol gene along with Gag antibody detection(More)
The infection dynamics and pathology of a retrovirus may be altered by one or more additional viruses. To investigate this further, this study characterized proviral load, biodistribution and the immune response in Macaca fascicularis naturally infected with combinations of simian retrovirus type 2 (SRV-2) and simian T-cell lymphotropic virus type I(More)
We compare the computational effectiveness of two different approaches to the autocalibration of environmental models: algorithms based on gridding the input parameter set; and genetic or evolutionary algorithms (GAs). Dramatic steps were taken to reduce the total run-time per simulation of the selected complex model in the calibration phase: a model that(More)
Flaviviruses related to hepatitis C virus (HCV) in suitable animal models may provide further insight into the role that cellular immunity contributes to spontaneous clearance of HCV. We characterised changes in lymphocyte populations in tamarins with an acute GBV-B infection, a hepatitis virus of the flaviviridae. Major immune cell populations were(More)
In retroviral co-infection one or more of the viruses may display altered dynamics impacting on the pathology within the host. To characterise the nature of such changes we studied cynomolgus macaques naturally infected with three retroviruses. DNA was isolated from eleven tissues from macaques infected with SFV-1 (4), SRV-2/SFV-1 (4), STLV-1/SFV-1 (3),(More)
Microsatellites are useful tools for ecologists and conservationist biologists, but are taxa-specific and traditionally expensive and time-consuming to develop. New methods using next-generation sequencing (NGS) have reduced these problems, but the plethora of software available for processing NGS data may cause confusion and difficulty for researchers new(More)
The snake-in-the-box problem is concerned with finding the longest induced path in a hypercube Qn. Similarly, the coil-in-the-box problem is concerned with finding the longest induced cycles in Qn. We consider a generalization of these problems, first studied in [Sin66], that considers paths and cycles where each pair of vertices at distance at least k in(More)
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