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Serum thymidine kinase in vitamin B12 deficiency.
In DNA synthesis deoxythymidine kinase (TK) catalyses the conversion of deoxythymidine to deoxythymidine monophosphate (dTMP) via the 'salvage pathway'. Serum deoxythymidine kinase (S-TK) wasExpand
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Comparison of diagnostic and prognostic performance of two assays measuring thymidine kinase 1 activity in serum of breast cancer patients
Abstract Background: We compared two recently developed immunoassays for serum thymidine kinase 1 (TK1) activity: one manual assay (DiviTum, Biovica®) and one fully automated assay (Liaison,Expand
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Deoxythymidine kinase in the staging of prostatic adenocarcinoma
The role of prostate‐specific antigen in the management of prostatic adenocarcinoma is still not fully ascertained. Its place in the monitoring of patients who have undergone radical treatment isExpand
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Serum thymidine kinase 1 activity in breast cancer.
AIMS Thymidine kinase 1 (TK1) is an enzyme involved in DNA synthesis and an important proliferation marker. We explored the association of preoperative serum TK1 activity with clinicopathologicalExpand
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Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
OBJECTIVES Pyruvate kinase type M2 (TuM2-PK) and thymidine kinase 1 (TK1) are the key enzymes involved in tumor cells metabolism and proliferation. We explored the association of their preoperativeExpand
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Serum thymidine kinase in acute leukaemia.
Deoxythymidine kinase (TK) catalyzes the phosphorylation of deoxythymidine to deoxythymidine monophosphate, an essential precursor of DNA thymine. Among the different isoenzymes of TK (ATP: thymidineExpand
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Serum thymidine kinase as a prognostic marker in Hodgkin's disease.
In 72 of 81 consecutively diagnosed patients with Hodgkin's disease pretreatment sera were available for analysis of serum thymidine kinase (S-TK) levels. In relation to clinical parameters, such asExpand
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Significance of amino acid substitutions in the thymidine kinase gene of herpes simplex virus type 1 for resistance.
The analysis of the viral thymidine kinase (TK) genotype is of rising significance for testing resistance of herpes simplex virus (HSV) to antivirals especially acyclovir. However, numerous of theExpand
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No evidence for spumavirus or oncovirus infection in relapsing–remitting multiple sclerosis
Polymerase chain reaction analysis was used to investigate the possible role of human spumaretrovirus and oncoretroviruses (human T‐cell lymphotropic virus types I {HTLV‐I} and II {HTLV‐II}) inExpand
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Serum levels of interleukin-2 receptor (CD 25) in patients with Hodgkin's disease, with special reference to age and prognosis.
BACKGROUND The serum levels of soluble interleukin-2 receptor (S-sIL-2R) have been shown to be related to clinical outcome in Hodgkin's disease (HD). sIL-2R may be involved in or aggravate theExpand
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