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We have explored the visuotopic organization of the territory surrounding the middle suprasylvian sulcus (MSS) of cat cerebral cortex by electrophysiological mapping, and by tracing the topography of its cortical and subcortical connections using wheatgerm-agglutinin horseradish peroxidase (WGA-HRP). Observations from the two approaches were concordant, and(More)
Theoretical considerations suggest that binocular information should provide advantages, compared to monocular viewing, for the planning and execution of natural reaching and grasping actions, but empirical support for this is quite equivocal. We have examined these predictions on a simple prehension task in which normal subjects reached, grasped and lifted(More)
Information processing in the brain is strongly constrained by anatomical connectivity. However, the principles governing the organization of corticocortical connections remain elusive. Here, we tested three models of relationships between the organization of cortical structure and features of connections linking 49 areas of the cat cerebral cortex. Factors(More)
Current hierarchical models of the cerebral cortex are mainly based on qualitative connection studies. From wheatgerm-agglutinin-horseradish peroxidase injections, we examined the laminar patterns of projections to and between the three major subdivisions of the motion-processing lateral suprasylvian (LS) complex [areas posteromedial lateral suprasylvian(More)
Regularity of laminar origin and termination of projections appears to be a common feature of corticocortical connections. We tested three models of this regularity, originally formulated for primate cerebral cortex, using quantitative data on the relative supragranular layer origins (SGN%) of 151 projections from 19 areas ( approximately 145,000 neurons)(More)
The dopamine transporter (DAT) is a primary site for the action of cocaine in inducing euphoria. Its action is necessary for the selectivities of dopaminergic neurotoxins that provide the best current experimental models of Parkinson's disease. In the present report, rat dopamine transporter-like immunoreactivity (iDAT) was assessed by immunohistochemistry(More)
PURPOSE To examine the effects of permanent versus brief reductions in binocular stereo vision on reaching and grasping (prehension) skills. METHODS The first experiment compared prehension proficiency in 20 normal and 20 adults with long-term stereo-deficiency (10 with coarse and 10 with undetectable disparity sensitivities) when using binocular vision(More)
The lateral suprasylvian (LS) area (or Clare-Bishop area) is a region of visual cortex in the cat which has been defined as an isolated projection zone of area 17 (V1 or striate cortex) within the suprasylvian sulcus. We have studied the overall topography and detailed pattern of connection between these two visual areas following injections of WGA-HRP into(More)
PURPOSE Visual defects associated with amblyopia have been extensively studied, but their impact on the performance of everyday visuomotor tasks is unclear. This study evaluates eye-hand coordination (prehension) skills in adult amblyopes compared with normal subjects. METHODS Twenty amblyopes (10 strabismic, 10 nonstrabismic) with different degrees of(More)
A question of increasing interest to the basic science and clinical management communities during the past decade is whether children and adults with amblyopia and associated binocular visual abnormalities experience difficulties in executing real-world actions, to which vision normally makes an important functional contribution. Here we provide objective(More)