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BACKGROUND AND PURPOSE Determining how cerebral cortex adapts to sudden focal damage is important for gaining a better understanding of stroke. In this study we used a computational model to examine the hypothesis that cortical map reorganization after a simulated infarct is critically dependent on perilesion excitability and to identify factors that(More)
The pathogenesis of penumbral tissue infarction during acute ischemic stroke is controversial. This peri-infarct tissue may subsequently die, or survive and recuperate, and its preservation has been a prime goal of recent therapeutic trials in acute stroke. Two major hypotheses currently under consideration are that penumbral tissue is recruited into an(More)
When a cerebral infarction occurs, surrounding the core of dying tissue there usually is an ischemic penumbra of nonfunctional but still viable tissue. One current but controversial hypothesis is that this penumbra tissue often eventually dies because of the metabolic stress imposed by multiple cortical spreading depression (CSD) waves, that is, by ischemic(More)
The paper describes the prototype design and development of a multimedia system for museums and galleries. Key elements in the system are the introduction of 3-D models of museum artefacts together with 3-D as well as 2-D content based retrieval and navigation facilities and the development of a semantic layer, centred on an ontology for museums, which aims(More)
It is often suggested that a major factor in diaschisis is the loss of transcallosal excitation to the intact hemisphere from the lesioned one. However, there is long-standing disagreement in the broader experimental literature about whether transcallosal interhemispheric influences in the human brain are primarily excitatory or inhibitory. Some(More)
This paper presents an updated technical overview of an integrated content and metadata-based image retrieval system used by several major art galleries in Europe including the Louvre in Paris, the Victoria and Albert Museum in London, the Uffizi Gallery in Florence and the National Gallery in London. In our approach, the subjects of a query (e.g. images,(More)
There is long-standing disagreement among experimentalists about whether transcallosal interhemispheric influences are primarily excitatory or inhibitory. Past computational models exploring this issue have encountered a similar dilemma: inhibitory callosal influences best explain hemispheric functional asymmetries, but excitatory callosal influences best(More)
This study provides two results: (1) a theorem that enables a shared resource scheduling problem to be transformed into an unshared resource problem; (2) a competitive activation-based neural network that enables the unshared resource scheduling problem to be solved. These results are used to find an optimal scheduling of antennas of low-level satellites.(More)