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BACKGROUND While cough is an important defence mechanism of the respiratory system, its chronic presence is bothersome and may indicate the presence of a serious disease. We hereby describe the validation process of a novel cough detection and counting technology (PulmoTrack-CC, KarmelSonix, Haifa, Israel). METHODS Tracheal and chest wall sounds, ambient(More)
A study was carried out to determine whether an episode of exercise-induced asthma (EIA) is followed by a refractory period and to assess the factors that affect it. Nine children, 9 to 14 years of age, were studied during repeated, paired exercise tests on a treadmill. Respiratory function was assessed by measuring peak expiratory flow rate before and(More)
A year-long double-blind trial was carried out in 53 asthmatic children with severe perennial symptoms who were not receiving corticosteroids or corticotrophin. The treatment group were given disodium cromoglycate with isoprenaline (Intal Co.) while the placebo group were given lactose with isoprenaline four times daily. The groups were closely matched for(More)
A study of the relation between physical signs and the clinical and physiological pattern of chronic lung disease with obstruction has been carried out on 24 patients with varying degrees of airways obstruction. One sign (the forced expiratory time) was a direct reflection of the obstruction , but a number of other signs which also correlated significantly(More)
  • Simon Godfrey
  • 2009
Wheezing and respiratory symptoms are very common in preschool children, and the ability to diagnose asthma correctly is important. This review describes an approach to the diagnosis of asthma in preschool children by means of an inhalation bronchial challenge. The child is exposed to increasing doses of challenge agent until wheezing is detected at a dose(More)
1. Cardiac output measured by transthoracic impedance cardiography has been compared with simultaneous measurements made by the indirect Fick CO2 rebreathing method in nine adults and 14 children. All were healthy normal volunteers. Sixty-six comparisons were made at rest and during steady exercise at work loads up to 100 W. 2. Impedance measurements of(More)
BACKGROUND Bronchial provocation tests such as exercise, methacholine (MCH), and adenosine-5'-monophosphate (AMP) challenges are used extensively in the diagnosis of asthma. A study was undertaken to determine whether exhaled nitric oxide (eNO) can be used to diagnose asthma in patients with non-specific respiratory symptoms and to compare this test with(More)
Twenty one children with asthma aged 1.0-10.5 years (mean (SD) 3.3 (2.5) years) were admitted to the hospital to evaluate pulmonary right middle lobe or lingular collapse lasting one to 12 months (mean (SD) 4.4 (3.8) months). Seven children had mild asthma and were treated with inhaled beta 2 agonists as needed. Nine had moderate asthma treated with either(More)
BACKGROUND Open lung biopsy (OLB) has long been considered the gold standard for the diagnosis of parenchymal lung disease. With recent advances in computed tomographic imaging and diagnostic techniques (eg, bronchoscopy), we thought it necessary to reevaluate the role of OLB in the management of patients with interstitial lung disease. METHODS We carried(More)
The steroid sparing effect of nebulised budesonide suspension was assessed in a double blind placebo controlled parallel group study of 36 preschool children with severe asthma who were dependent on treatment with oral steroids. Nebulised budesonide suspension significantly reduced the requirement for treatment with oral steroids, and produced a marked(More)