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Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.
TLDR
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis, so representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition. Expand
Second symposium on the definition and management of anaphylaxis: summary report--second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.
TLDR
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis, so representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition. Expand
Clinical features and severity grading of anaphylaxis.
TLDR
A simple grading system and definition of anaphylaxis has potential value for defining reaction severity in clinical practice and research settings and appears to be the major determinants of reaction severity. Expand
Thrombolysis in acute ischaemic stroke
TLDR
This monograph presents a meta-analysis of thrombolysis with alteplase 3 to 4·5 hours after acute ischemic stroke with findings that support the use of rt-PA for ischaemic stroke. Expand
Determinants of severe hypoglycemia complicating type 2 diabetes: the Fremantle diabetes study.
TLDR
Lower fasting serum glucose and higher glycosylated hemoglobin were significantly associated with frequency, whereas patients at minimal risk of repeated severe hypoglycemia were unlikely to use insulin or to have short-duration insulin treatment, to have renal impairment or peripheral neuropathy, or to be educated beyond primary level. Expand
Anaphylaxis: clinical patterns, mediator release, and severity.
TLDR
The results suggest that multiple inflammatory pathways drive reaction severity and support recommendations for safe observation periods after initial treatment. Expand
Clinical Effects and Antivenom Dosing in Brown Snake (Pseudonaja spp.) Envenoming — Australian Snakebite Project (ASP-14)
TLDR
Accumulating evidence is supported that giving more than one vial of antivenom is unnecessary in brown snake envenoming, and the results of this study support accumulating evidence. Expand
2. Anaphylaxis: diagnosis and management
TLDR
The cornerstones of initial management are putting the patient in the supine position, administering intramuscular adrenaline into the lateral thigh, resuscitation with intravenous fluid, support of the airway and ventilation, and giving supplementary oxygen. Expand
Conservative versus Interventional Treatment for Spontaneous Pneumothorax.
TLDR
Although the primary outcome was not statistically robust to conservative assumptions about missing data, the trial provides modest evidence that conservative management of primary spontaneous pneumothorax was noninferior to interventional management, with a lower risk of serious adverse events. Expand
Can serum mast cell tryptase help diagnose anaphylaxis?
TLDR
Clinicians should use caution when using serum tryptase to refute or support a diagnosis of anaphylaxis, and further studies using serialtryptase determinations in general emergency department practice, perhaps supplemented by histamine determinations are warranted. Expand
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