Simon Flexner

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The data brought together in this report have been gathered from a wide territory and for a period extending over several years. The antimeningitis serum was first employed in 1906 and the latest figures relating to its use included in this report were furnished in 1912. There is no longer doubt that the serum has come to be applied under conditions fairly(More)
The origin of many eases of acute inflammation of the pancreas in a diversioxl of the biliary secretion from the intestine into the pancreatic duct has been established by Opie's 1 observation and experiments. His experiments did not, however, take into account the nature of the biliarv constituent which excites the inflammatory and other changes, neither(More)
The experimental study of poliomyelitis has yielded a large number of important facts relating to the spontaneous disease in man. The nature of the virus has been discovered, many of its properties have been ascertained, some of its immunity effects have been established, the clinical and pathological peculiarities of the disease have been elucidated, and a(More)
C O N T E N T S . PA.GE. INTRODUCTION. GENERAL CONSIDERATIONS CONCERNING H ~ M O L Y S I S AND BACTERIOLYSIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277 VENOM-.AGGLUTINATIO~ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 283(More)
IN November, 1891, one of us (Welch ~), at a meeting of the Johns Hopkins Hospital Medical Society, reported with demonstrations the discovery of a gas-forming bacillus found in the eml)hysematous tissues and blood of a man dead of aneurism of the aorta. In JulyAugust, 1892, Welch and Nuttall published a full report of this case and described the characters(More)
It is our belief that the analyses of histories of cases of epidemic meningitis which have been presented in this article furnish convincing proof that the antimeningitis serum when used by the subdural method of injection, in suitable doses and at proper intervals, is capable of reducing the period of illness; of preventing, in large measure, the chronic(More)
Several attempts have been made to demonstrate under the microscope and to develop in artificial cultures the microSrganism causing epidemic poliomyelitis, but hitherto unsuccessfully. Giersvold 1 cultivated certain micrococci from the cerebrospinal fluid, and Fox 2 a bacillus from the circulating blood of poliomyelitic patients, but both have now been(More)
During the prevalence of the epidemics of cerebro-spinal meningitis in America and Europe from 19o 4 to 19o 7 Diplococcus intracellularis, discovered by Weichselbaum in 1887, was established finally as the cause of epidemic meningitis. In the course of the studies of this microorganism carried out by one of us (Flexnet1), as one of a commission appointed by(More)
A strain of the poliomyelitic virus was propagated in monkeys for four years, during which time it displayed three distinct phases of virulence. The several phases covered different periods of time. At the outset the virulence was low, but by animal passages it quickly rose to a maximum; this maximum was maintained for about three years, when, without known(More)
The minute microörganism cultivated from poliomyelitic tissues survives and maintains its pathogenicity in cultures for more than one year. Upon inoculation into monkeys poliomyelitis may fail to appear upon the first injection and yet follow from the effects of successive injections of the culture. Inoculations of cultures into monkeys which fail to(More)