Simon Flexner

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The data brought together in this report have been gathered from a wide territory and for a period extending over several years. The antimeningitis serum was first employed in 1906 and the latest figures relating to its use included in this report were furnished in 1912. There is no longer doubt that the serum has come to be applied under conditions fairly(More)
It is our belief that the analyses of histories of cases of epidemic meningitis which have been presented in this article furnish convincing proof that the antimeningitis serum when used by the subdural method of injection, in suitable doses and at proper intervals, is capable of reducing the period of illness; of preventing, in large measure, the chronic(More)
The experimental study of poliomyelitis has yielded a large number of important facts relating to the spontaneous disease in man. The nature of the virus has been discovered, many of its properties have been ascertained, some of its immunity effects have been established, the clinical and pathological peculiarities of the disease have been elucidated, and a(More)
Several attempts have been made to demonstrate under the microscope and to develop in artificial cultures the microSrganism causing epidemic poliomyelitis, but hitherto unsuccessfully. Giers-vold 1 cultivated certain micrococci from the cerebrospinal fluid, and Fox 2 a bacillus from the circulating blood of poliomyelitic patients, but both have now been(More)
The guinea pig is subject to cerebral and corneal inoculation of the herpes virus. The effects of the inoculations vary with the strength or degree of virulence of the virus. Weak strains of the virus are implanted on the cerebrum with difficulty and strong strains with ease. Weak strains are quickly suppressed by the brain and strong strains may be passed(More)
The study of the effects of the living pathogenic organisms upon the animal body has been succeeded by an era in which especial atten-t-ion has been directed to the influence of their soluble products. The researches of Oertel* upon human diphtheria, of Babes t and of Welch and Flexner$ upon the experimental form of the disease, the latter including the(More)
A strain of the poliomyelitic virus was propagated in monkeys for four years, during which time it displayed three distinct phases of virulence. The several phases covered different periods of time. At the outset the virulence was low, but by animal passages it quickly rose to a maximum; this maximum was maintained for about three years, when, without known(More)
The high mortality of epidemic meningitis and the deplorable deformities caused by it demand that incessant effort be made to discover therapeutic measures which may mitigate the consequences of the disease. The epidemic through which the city of New York has recently passed, and the almost co-incident Silesian epidemic, have been scientifically fruitful in(More)
The minute microörganism cultivated from poliomyelitic tissues survives and maintains its pathogenicity in cultures for more than one year. Upon inoculation into monkeys poliomyelitis may fail to appear upon the first injection and yet follow from the effects of successive injections of the culture. Inoculations of cultures into monkeys which fail to(More)