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GlycoDelete engineering of mammalian cells simplifies N-glycosylation of recombinant proteins
Heterogeneity in the N-glycans on therapeutic proteins causes difficulties for protein purification and process reproducibility and can lead to variable therapeutic efficacy. This heterogeneityExpand
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Membrane vesicle secretion and prophage induction in multidrug‐resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress
Several bacterial species produce membrane vesicles (MVs) in response to antibiotic stress. However, the biogenesis and role of MVs in bacterial antibiotic resistance mechanisms have remainedExpand
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Intra- and Interspecies Effects of Outer Membrane Vesicles from Stenotrophomonas maltophilia on β-Lactam Resistance
ABSTRACT The treatment of Stenotrophomonas maltophilia infection with β-lactam antibiotics leads to increased release of outer membrane vesicles (OMVs), which are packed with two chromosomallyExpand
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The Role of Bacterial Secretion Systems in the Virulence of Gram-Negative Airway Pathogens Associated with Cystic Fibrosis
Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene. A defect in the CFTR ion channelExpand
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The effect of imipenem and diffusible signaling factors on the secretion of outer membrane vesicles and associated Ax21 proteins in Stenotrophomonas maltophilia
Outer membrane vesicles (OMVs) are small nanoscale structures that are secreted by bacteria and that can carry nucleic acids, proteins, and small metabolites. They can mediate intracellularExpand
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Off-target glycans encountered along the synthetic biology route towards humanized N-glycans in Pichia pastoris
Background The glycosylation pathways of several eukaryotic protein expression hosts are being engineered to enable the production of therapeutic glycoproteins with humanized application-customizedExpand
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Unconventional Gas in the Benelux: Cautious Attitudes and Regional Interplay
The three countries of the Benelux are often overlooked in Europe’s current unconventional gas debate. But the Netherlands, Belgium and Luxembourg all possess considerable shale gas resources, andExpand
Off‐target glycans encountered along the synthetic biology route toward humanized N‐glycans in Pichia pastoris
The glycosylation pathways of several eukaryotic protein expression hosts are being engineered to enable the production of therapeutic glycoproteins with humanized application‐customized glycanExpand