Learn More
OBJECTIVES To determine whether the use of medications with possible and definite anticholinergic activity increases the risk of cognitive impairment and mortality in older people and whether risk is cumulative. DESIGN A 2-year longitudinal study of participants enrolled in the Medical Research Council Cognitive Function and Ageing Study between 1991 and(More)
BACKGROUND Agitation in Alzheimer's disease (AD) is common and associated with poor patient life-quality and carer distress. The best evidence-based pharmacological treatments are antipsychotics which have limited benefits with increased morbidity and mortality. There are no memantine trials in clinically significant agitation but post-hoc analyses in other(More)
Hemi-spatial neglect is an attentional disorder in which the sufferer fails to acknowledge or respond to stimuli appearing in contralesional space. In recent years, it has become clear that a measurable reduction in contralesional neglect can occur during galvanic vestibular stimulation, a technique by which transmastoid, small amplitude current induces(More)
OBJECTIVE to examine the effect of medications with anticholinergic effects on cognitive impairment and deterioration in Alzheimer's dementia (AD). METHODS cognitive function was measured at baseline and at 6- and 18-month follow-up using the Mini-Mental State Exam (MMSE), the Severe Impairment Battery (SIB) and the Alzheimer's Disease Assessment Battery,(More)
Objectives Firstly, to compare the effectiveness of a brief physiotherapy intervention with " usual " physiotherapy for patients with neck pain. Secondly, to evaluate the effect of patients' preferences on outcome. Design Non-inferiority randomised controlled trial eliciting preferences independently of randomisation. Setting Physiotherapy departments in a(More)
AIMS To identify client characteristics that predict attendance at treatment sessions and to investigate the effect of attendance on outcomes using data from the UK Alcohol Treatment Trial. METHODS Logistic regression was used to determine whether there were characteristics that could predict attendance and then continuation in treatment. Linear(More)
OBJECTIVES Firstly, to compare the effectiveness of a brief physiotherapy intervention with "usual" physiotherapy for patients with neck pain. Secondly, to evaluate the effect of patients' preferences on outcome. DESIGN Non-inferiority randomised controlled trial eliciting preferences independently of randomisation. SETTING Physiotherapy departments in(More)
OBJECTIVE To evaluate the effectiveness of different brief intervention strategies at reducing hazardous or harmful drinking in primary care. The hypothesis was that more intensive intervention would result in a greater reduction in hazardous or harmful drinking. DESIGN Pragmatic cluster randomised controlled trial. SETTING Primary care practices in the(More)
The prevalence of both obesity and disability is increasing globally and there is now growing evidence to suggest that these two health priorities may be linked. This paper explores the evidence linking obesity to muscular-skeletal conditions, mental health disorders and learning disabilities in both adult and child populations. The impact of obesity on the(More)
OBJECTIVE To compare the clinical effectiveness of doctors and nurses in undertaking upper and lower gastrointestinal endoscopy. DESIGN Pragmatic trial with Zelen's randomisation before consent to minimise distortion of existing practice. SETTING 23 hospitals in the United Kingdom. In six hospitals, nurses undertook both upper and lower gastrointestinal(More)