Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes.
- B. Goodpaster, J. He, Simon C Watkins, D. Kelley
- MedicineJournal of Clinical Endocrinology and Metabolism
- 1 December 2001
Skeletal muscle of trained endurance athletes is markedly insulin sensitive and has a high oxidative capacity, despite having an elevated lipid content, according to quantitative image analysis of Oil Red O staining.
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
Red redistribution of cardiolipin serves as an ‘eat-me’ signal for the elimination of damaged mitochondria from neuronal cells as well as the engulfment of mitochondria by the autophagic system.
Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells.
It is demonstrated that exosomes also are internalized and processed by immature DCs for presentation to CD4(+) T cells, implying that exOSomes present in circulation or extracellular fluids constitute an alternative source of self- or allopeptides for DCs during maintenance of peripheral tolerance or initiation of the indirect pathway of allorecognition in transplantation.
Negative inotropic effects of cytokines on the heart mediated by nitric oxide.
- M. Finkel, C. V. Oddis, T. Jacob, Simon C Watkins, B. Hattler, R. Simmons
- Biology, MedicineScience
- 17 July 1992
The findings demonstrate that the direct negative inotropic effect of cytokines is mediated through a myocardial nitric oxide synthase, and the regulation of pro-inflammatory cytokines and myocardia nitricoxide synthase may provide new therapeutic strategies for the treatment of cardiac disease.
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.
It is discovered that ferroptosis involves a highly organized oxygenation center, wherein oxidation in endoplasmic-reticulum-associated compartments occurs on only one class of phospholipids (phosphatidylethanolamines (PEs) and is specific toward two fatty acyls-arachidonoyl (AA) and AdA (AdA).
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo.
- J. Grandis, S. Drenning, J. Kim
- Medicine, BiologyProceedings of the National Academy of Sciences…
- 11 April 2000
Analysis of the expression and constitutive activation of Stat3 in tumors and normal mucosa from patients with head and neck cancer provides evidence that constitutively activated Stat3 is an early event in head and head carcinogenesis that contributes to the loss of growth control by an anti-apoptotic mechanism.
Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.
It is demonstrated that DCs release exosomes with different miRNAs depending on the maturation of the DCs, and exosome-shuttle miRNAAs are functional, because they repress target mRNAs of acceptor DCs.
Std1 and Mth1 Proteins Interact with the Glucose Sensors To Control Glucose-Regulated Gene Expression in Saccharomyces cerevisiae
Genetic interactions between STD1, MTH1, SNF3, andRGT2 suggest that the glucose signaling is mediated, at least in part, through interactions of the products of these four genes.
DNA–based immunization by in vivo transfection of dendritic cells
- Cal Condon, Simon C Watkins, C. Celluzzi, K. Thompson, L. Falo
- Biology, MedicineNature Network Boston
- 1 October 1996
It is shown that cutaneous genetic immunization with naked DNA results in potent, antigen–specific, cytotoxic T lymphocyte–mediated protective tumor immunity and the feasibility of genetically engineering dendritic cells in vivo.
Disabled‐2 exhibits the properties of a cargo‐selective endocytic clathrin adaptor
- Sanjay Mishra, Peter A Keyel, Matthew J. Hawryluk, N. Agostinelli, Simon C Watkins, L. Traub
- BiologyEMBO Journal
- 16 September 2002
It is proposed that Dab2 is a typical member of a growing family of cargo‐specific adaptor proteins, including β‐arrestin, AP180, epsin, HIP1 and numb, which regulate clathrin‐coat assembly at the plasma membrane by synchronizing cargo selection and lattice polymerization events.