Simon A. Watson

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Solid-state NMR (SSNMR) can provide detailed structural information about amorphous solid dispersions of pharmaceutical small molecules. In this study, the ability of SSNMR experiments based on dipolar correlation, spin diffusion, and relaxation measurements to characterize the structure of solid dispersions is explored. Observation of spin diffusion(More)
Nuclear magnetic resonance spectroscopy was used to determine oil content of individual corn kernels in order to evaluate this technique as an aid in the development of strains having greater oil content. This method is rapid and does not impair viability. Individual kernels from a selfed single-cross ear ranged from 2.7 to 5.4 percent oil and were(More)
The DMAIC (Define, Measure, Analyse, Improve and Control) framework and associated statistical tools have been applied to both identify and reduce variability observed in a quantitative (19)F solid-state NMR (SSNMR) analytical method. The method had been developed to quantify levels of an additional polymorph (Form 3) in batches of an active pharmaceutical(More)
Nuclear power provides a significant portion of our current energy demand and is likely to become more wide spread with growing world population. However, the radioactive waste generated in these power plants must be stored for around 60 years in underwater storage pools before permanent disposal. These underwater storage environments must be carefully(More)
The development of small-scale sensor platforms for the internal monitoring of aqueous processes creates a range of challenges in terms of the provision of mobility. De-coupled x-y plane and z-axis movement, the need for low power consumption and a minimum of 4 degrees of freedom means that the suitability of conventional propulsion systems needs to be(More)
Micro-Autonomous Underwater Vehicles (μAUVs) can form the basis of mobile underwater sensor networks for monitoring sub-surface cluttered environments. There are numerous technical challenges involved in constructing such vehicles using off-the-shelf components. This paper presents progress to date in the design of such a system, the problems(More)
Micro-Autonomous Underwater Vehicles (μAUVs) can be used as part of underwater sensor networks in to monitor industrial processes. The high manoeuvrability requirements dictate that traditional AUV designs are not suitable. A prototype μAUV has been developed with independent movement capabilities in the horizontal and vertical planes. This(More)
Mobile Underwater Sensor Networks provide an attractive solution to the problem of obtaining measurements from within liquid-based industrial processes. Most underwater vehicles are aimed at oceanographic applications and are therefore too large to be used in comparatively small processes. This paper sets out the design considerations for the development of(More)
Swarms of micro-autonomous underwater vehicles (μAUVs) are an attractive solution to the problem of nuclear storage pond monitoring. Independent movement in the horizontal and vertical planes is necessary to maximize manoeuvrability. This paper presents a comparison of different control strategies for independent depth control using both simulations and(More)