Simin Luo

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Chondroid cell from human adipose-derived stem cells (ADSCs) has emerged as an alternative treatment option for articular cartilage defects. Herein, we successfully compared ADSCs, normal chondrocytes, and chondroid cells. The comparative study of ADSCs and chondroid cells revealed type II collagen (COL II) and glycosaminoglycans expression of chondroid(More)
OBJECTIVE The aim of this study was to compare the difference between insulin-producing cells (IPCs) and normal human pancreatic beta cells both in physiological function and morphological features in cellular level. METHODS The levels of insulin secretion were measured by enzyme-linked immunosorbent assay. The insulin gene expression was determined by(More)
We successfully differentiated human adipose tissue-derived mesenchymal stem cells (haMSCs) into insulin-producing cells (IPCs) in vitro and did not use any insulin which might be absorbed by cells during in vitro culture. Expression of insulin gene was massively increased by 28,000-fold at day 12 compared with haMSCs (P < 0.05). IPCs could secrete insulin(More)
Background. Studies revealed that metabolic factors might contribute substantially to osteoarthritis (OA) pathogenesis. There has been an increasing interest to understand the relationship between knee OA and the metabolic syndrome (MetS). The purpose of this study was to explore the association between metabolic syndrome and knee osteoarthritis using(More)
BACKGROUND Hematoma formation around the knee is commonly seen after total knee arthroplasty (TKA) and may cause patient discomfort and worry regarding the success of the surgery. This study aimed to evaluate the coagulation functions and hemorheological parameters in patients undergoing TKA and investigate their associations with hematoma formation. (More)
It has been suggested that microRNA-9 (miR-9) is associated with the development of knee osteoarthritis (OA). This study was aimed to investigate the association between the mechanism of miR-9 targeting nuclear factor kappa-B1 (NF-κB1) and the proliferation and apoptosis of knee OA chondrocytes.Cartilage samples were collected from 25 patients with knee OA(More)
Outlier detection is a very important type of data mining, which is extensively used in application areas. The traditional cell-based outlier detection algorithm not only takes a large amount of time in processing massive data, but also uses lots of machine resources, which results in the imbalance of the machine load. This paper presents an algorithm of(More)
OBJECTIVE The aim of this study is to probe the intrinsic mechanism of chondroid cell dedifferentiation in order to provide a feasible solution for this in cell culture. METHODS Morphological and biomechanical properties of cells undergoing chondrogenic differentiation from human adipose-derived stem cells (ADSCs) were measured at the nanometer scale(More)
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