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A nutrient-limited model for avascular cancer growth including cell proliferation, motility, and death is presented. The model qualitatively reproduces commonly observed morphologies for primary tumors, and the simulated patterns are characterized by its gyration radius, total number of cancer cells, and number of cells on tumor periphery. These very(More)
Recent work has shown that different theoretical approaches to the dynamics of the susceptible-infected-susceptible (SIS) model for epidemics lead to qualitatively different estimates for the position of the epidemic threshold in networks. Here we present large-scale numerical simulations of the SIS dynamics on various types of networks, allowing the(More)
One of the most promising strategies to treat cancer is attacking it with viruses. Oncolytic viruses can kill tumor cells specifically or induce anticancer immune response. A multiscale model for virotherapy of cancer is investigated through simulations. It was found that, for intratumoral virus administration, a solid tumor can be completely eradicated or(More)
Recently, we have proposed a nutrient-limited model for the avascular growth of tumors including cell proliferation, motility, and death [S. C. Ferreira, Jr., M. L. Martins, and M. J. Vilela, Phys. Rev. E 65, 021907 (2002)], which qualitatively reproduces commonly observed morphologies for carcinomas in situ. In the present work, we analyze the effects of(More)
We investigate the effects of local population structure in reaction-diffusion processes representing a contact process (CP) on metapopulations represented as complex networks. Considering a model in which the nodes of a large scale network represent local populations defined in terms of a homogeneous graph, we show by means of extensive numerical(More)
We present high-accuracy quasistationary (QS) simulations of the contact process in quenched networks, built using the configuration model with both structural and natural cutoffs. The critical behavior is analyzed in the framework of the anomalous finite-size scaling which was recently shown to hold for the contact process on annealed networks. It turns(More)
We provide numerical evidence for slow dynamics of the susceptible-infected-susceptible model evolving on finite-size random networks with power-law degree distributions. Extensive simulations were done by averaging the activity density over many realizations of networks. We investigated the effects of outliers in both highly fluctuating (natural cutoff)(More)
The epidemic threshold of the susceptible-infected-susceptible (SIS) dynamics on random networks having a power law degree distribution with exponent γ>3 has been investigated using different mean-field approaches, which predict different outcomes. We performed extensive simulations in the quasistationary state for a comparison with these mean-field(More)
One of the most promising strategies to treat cancer is attacking it with viruses. Virus can kill tumor cells specifically or act as carriers that deliver normal genes into cancer cells. A model for virus therapy of cancer is investigated and some of its predictions are in agreement with results obtained from experimental tumors. Furthermore, the model(More)
One of the most promising strategies to treat cancer is attacking it with viruses designed to exploit specific altered pathways. Here, the effects of oncolytic virotherapy on tumors having compact, papillary, and disconnected morphologies are investigated through computer simulations of a multiscale model coupling macroscopic reaction-diffusion equations(More)