Silvija Coulter

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RATIONALE Chronic obstructive lung disease (COPD) is a common and disabling lung disease for which there are few therapeutic options. OBJECTIVES We reasoned that gene expression profiling of COPD lungs could reveal previously unidentified disease pathways. METHODS Forty-eight human lung samples were obtained from tissue resected from five nonsmokers, 21(More)
BACKGROUND Increased small airway resistance and decreased lung elasticity contribute to the airflow limitation in chronic obstructive pulmonary disease (COPD). The lesion that corresponds to loss of lung elasticity is emphysema; the small airway obstruction is due to inflammatory narrowing and obliteration. Despite their convergence in altered physiology,(More)
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