Silvia Regazzoni

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BACKGROUND Third-line chemotherapies for advanced breast cancer are difficult to tailor to the individual patient because of reduced tolerance and significant toxicity. Treatment with a continuous intravenous infusion of low-dose 5-fluorouracil (FU-LDCI) is generally well tolerated and thus, a reasonable option for heavily pretreated patients. PATIENTS(More)
CARD15 on chromosome 16 is the only IBD susceptibility gene identified among several mapped loci. Its recurrent variants R702W, G908R and L1007fs have shown significant association with Crohn's disease (CD), but not with ulcerative colitis (UC), in different Caucasian populations. We analysed these three variants in 184 CD and 92 UC Italian patients and in(More)
PURPOSE XRCC1 and XPD play key roles in the repair of DNA lesions and adducts. Contrasting findings have been reported on the effect of polymorphisms of these genes on the response to platinum-based chemotherapy in advanced non-small-cell lung cancer (NSCLC). This study aimed to investigate the relationship between the XPD Lys751Gln and XRCC1 Arg399Gln(More)
Location information is of paramount importance in context aware Ambient Intelligence (AmI), Smart Space, traffic monitoring, surveillance network and cooperative communications services. This paper describes a Positioning determination solution based on wireless local area network (WLAN) signals. Position determination is based on the statistical modeling(More)
OBJECTIVE To evaluate to what extent an inefficient statistical model affects the study of genetic factors in extra-intestinal manifestations of Crohn's disease (CD) and how clinical predictions can be improved using more adequate techniques. MATERIALS Extra-intestinal manifestations were studied in 152 CD patients. Three sets of variables were(More)
Many client based positioning systems using received signal strength (RSS) ofWLAN (Wireless Local Area Network) are present in the state-of-art. Unfortunately, location precision is limited in most of the cases. Researchers have proposed to integrate different systems to enhance accuracy and coverage which brings a necessity to have a trade off solution(More)
INTRODUCTION Causative mutations leading to congenital quantitative fibrinogen are frequently clustered in FGA encoding the fibrinogen Aα-chain. Mutations of FGB encoding the Bβ-chain are less common and of interest since the Bβ-chain is considered the rate-limiting factor in the hepatic production of the fibrinogen hexamer. METHOD Four novel FGB(More)
2500 Background: Cisplatin and derivatives represent the cornerstone drugs in lung cancer treatment. Nevertheless, treatment related toxicities are sometime relevant and survival is still limited. Platinum-based compounds act by forming DNA adducts and cross-links which are recognized and repaired through the NER repair pathway. The efficacy of platinum(More)
Ataxia-telangiectasia (AT) is a rare recessive disease with pleiotropic involvement of the nervous and lymphoid systems. AT heterozygotes have a population frequency of about 1%, and although not manifesting any overt clinical symptoms, they have an increased mortality, mainly because of cancer and ischemic heart disease. We and others have described a(More)
The clinical data on terminal cancer patients who have died since the establishment of a program of collaboration between community services and the cancer center of Canton of Ticino, southern Switzerland, were retrospectively analyzed to describe the characteristics of patients seen and the effect on them of a home-care program coordinated by the cancer(More)