Silvia Gazzola

Learn More
A library of functionalized chemical probes capable of reacting with ketosynthase-bound biosynthetic intermediates was prepared and utilized to explore in vivo polyketide diversification. Fermentation of ACP mutants of S. lasaliensis in the presence of the probes generated a range of unnatural polyketide derivatives, including novel putative lasalocid A(More)
SUMMARY This paper introduces a new strategy for setting the regularization parameter when solving large-scale discrete ill-posed linear problems by means of the Arnoldi-Tikhonov method. This new rule is essentially based on the discrepancy principle, although no initial knowledge of the norm of the error that affects the right-hand side is assumed; an(More)
This paper introduces two new algorithms, belonging to the class of Arnoldi-Tikhonov regularization methods, which are particularly appropriate for sparse reconstruction. The main idea is to consider suitable adaptively-defined regularization matrices that allow the usual 2-norm regularization term to approximate a more general regularization term expressed(More)
  • 1