Maurizio Caniglia1
Andrea Finocchi1
Alessia Funari1
Maria L. Romiti1
Alessandra Simonetti1
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  • Benedetto Sacchetti, Alessia Funari, Stefano Michienzi, Silvia Di Cesare, Stefania Piersanti, Isabella Saggio +5 others
  • 2007
The identity of cells that establish the hematopoietic microenvironment (HME) in human bone marrow (BM), and of clonogenic skeletal progenitors found in BM stroma, has long remained elusive. We show that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident(More)
  • Manuela Pellegrini, Sara Di Siena, Giuseppina Claps, Silvia Di Cesare, Susanna Dolci, Pellegrino Rossi +2 others
  • 2010
A critical step of spermatogenesis is the entry of mitotic spermatogonia into meiosis. Progresses on these topics are hampered by the lack of an in vitro culture system allowing mouse spermatogonia differentiation and entry into meiosis. Previous studies have shown that mouse pachytene spermatocytes cultured in simulated microgravity (SM) undergo a(More)
Hematopoietic cell transplantation (HCT) provides a curative therapy for severe forms of primary immunodeficiencies (PID). While the timing and extent of T-cell reconstitution following transplant for PID has been studied in depth, less is known about the kinetics of B-cell development and long-term restoration of humoral functions, which been often(More)
BACKGROUND Thymus organogenesis and T lymphocyte development are accomplished together during fetal life. Proper development and maintenance of thymus architecture depend on signals generated by a sustained crosstalk between developing thymocytes and stromal elements. Any maturation impairment occurring in either cellular component leads to an aberrant(More)
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