Learn More
Senosory neurons manifest pronounced changes in excitability during maturation, but the factors contributing to this ubiquitous developmental phenomenon are not well understood. To assess the contribution of intrinsic membrane properties to such changes in excitability, in the present study whole cell patch-clamp recordings were made from developing(More)
Calcium calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) was identified in crude extract and immunolabeled sections of rat retina. Both cAMP and cGMP PDE activities were stimulated by calcium-calmodulin (4.7-fold and 2.3-fold, respectively). To characterize PDE1 isoforms in retinal cells further, we used antibodies that specifically recognize(More)
Electroretinographic responses (ERG) to homogeneous light flashes and to alternating gratings were recorded from either eye of monkeys in which one optic nerve had been previously sectioned. Three weeks after optic nerve section the ERG response of the operated eye to alternating gratings was drastically reduced in amplitude and 5 weeks after surgery it was(More)
1. In seventy-six penetrations through areas 17 and 18 of the cat, neurones were regularly sampled at intervals of 100 micrometers and preferred orientation, optimal spatial frequency and resolving power were determined for each neurone in response to drifting sinusoidal gratings. 2. As already shown for area 17, in tangential penetrations through area 18,(More)
The spatial and temporal response properties of neurones of areas 17 and 18 were studied in single units (165) of anaesthetized and paralysed cats. The visual stimuli were drifting or alternating gratings. We confirmed and extended the observation by Tolhurst & Movshon (1975) showing that the spatial-frequency characteristics of neurones of area 17 are(More)
We have recorded steady-state PERGs from five macaque monkeys in response to red-green plaid patterns reversed sinusoidally in contrast. The patterns had either a pure luminance contrast (red-black, green-black, yellow-black), pure red-green color contrast, or a variable amount of luminance and color contrast. By varying the relative luminance of the(More)
PURPOSE To identify the genes and noncoding RNAs (ncRNAs) involved in the neuroprotective actions of a dietary antioxidant (saffron) and of photobiomodulation (PBM). METHODS We used a previously published assay of photoreceptor damage, in which albino Sprague Dawley rats raised in dim cyclic illumination (12 h 5 lux, 12 h darkness) were challenged by 24 h(More)
Experiments have been performed on unanaesthetized and paralysed cats. The tuning curves for spatial frequency of retinal, lateral geniculate and simple and complex cells of the cortex have been determined in response to sinusoidal gratings of various spatial frequencies at different levels of mean luminance. For all neurones, decreasing the mean luminance(More)
We have analyzed the effect of a small lesion to the retina of a two-day-old kitten and observed that after degeneration of ganglion cells whose axons were severed, a restricted region of the retina remained depleted of cells. Cells located near the borders of the depleted zone showed an abnormal elongation of dendrites towards the bare area. By means of a(More)