Silvanie Volz

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PURPOSE In neocortical epilepsies not satisfactorily responsive to systemic antiepileptic drug therapy, local application of antiepileptic agents onto the epileptic focus may enhance treatment efficacy and tolerability. We describe the effects of focally applied valproate (VPA) in a newly emerging rat model of neocortical epilepsy induced by tetanus toxin(More)
PURPOSE Pharmacotherapy of epilepsies is limited due to low concentrations at epileptogenic foci, side effects of high systemic doses and that some potentially efficient substances do not pass the blood-brain barrier. To overcome these limitations, we tested the efficacy of local valproate (VPA)-containing polymer implants in a model of necocortical(More)
Linear Brownian motors utilize relatively weak electric fields to bias the diffusion of particles in a microfluidic channel thereby harnessing Brownian motion to facilitate particle transport. We present a custom simulator for such a system and use it to optimize transport by modifying the electrode configuration and rectification scheme. With insight(More)
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