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PilC1, a pilus-associated protein in Neisseria menin- gitidis, is a key element in initial meningococcal adhesion to target cells. A promoter element (CREN, contact regulatory element of Neisseria)… (More)
Fluoroquinolone resistance in Streptococcus pyogenes has been described only anecdotally. In this study we describe two invasive ciprofloxacin-resistant S. pyogenes isolates (ciprofloxacin MICs, 8… (More)
A novel hypoxically regulated intercellular junction protein (claudin-like protein of 24 kDa, CLP24) has been identified that shows homology to the myelin protein 22/epithelial membrane protein… (More)
Abstract Simple Sequence Repeats (SSRs), also known as microsatellites, have not been used extensively to study the genetic diversity of pineapple ( Ananas comosus (L.) Merrill). In this work the… (More)
In classical forward genetics, genes were defined by the resulting phenotype. Later, analysis of individual genes at the molecular level became possible. The develop-ment of high-throughput methods… (More)
With the lack of tools available to manipulate the rat genome, alternative technologies have been investigated to generate loss-of-function rat models by gene invalidation. The recent demonstration… (More)