Silke S. Johannsen

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AIMS To evaluate the diagnostic performance of high-sensitivity troponin I (hsTnI) and other novel biomarkers for diagnosing non-ST-segment elevation myocardial infarction (NSTEMI) in patients with atrial fibrillation. METHODS In an acute chest pain cohort (N=1673), mean age 61.4±13.6 (34% female), we measured hsTnI and 13 established and novel biomarkers(More)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) provide a unique opportunity to study human heart physiology and pharmacology and repair injured hearts. The suitability of hiPSC-CM critically depends on how closely they share physiological properties of human adult cardiomyocytes (CM). Here we investigated whether a 3D engineered heart(More)
Vorhofflimmern (VHF) ist eine Erkrankung mit zunehmender klinischer und gesundheitspolitischer Bedeutung. Wir beschreiben die aktuelle Verteilung der Risikofaktoren und ihre Bedeutung in der Allgemeinbevölkerung. Bei 10.000 Teilnehmern der populationsbasierten Gutenberg Health Study (medianes Alter 56 Jahre, 49% Frauen) wurden die klassischen Risikofaktoren(More)
OBJECTIVE Nitric oxide produced from l-arginine is central to vascular homeostasis. Little is known about the relationship between arginine derivatives including asymmetric dimethylarginine (ADMA) and non-invasive vascular function measures in the general population. APPROACH AND RESULTS In 5000 individuals (median age 56; 25th/75th percentile: 46, 65;(More)
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