Skip to search formSkip to main contentSkip to account menu
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
TLDR
The data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling.
View PDF
Two Distinct Pathways Remove Mammalian Cohesin from Chromosome Arms in Prophase and from Centromeres in Anaphase
View on Elsevier
Dissociation of Cohesin from Chromosome Arms and Loss of Arm Cohesion during Early Mitosis Depends on Phosphorylation of SA2
TLDR
The analysis of these cells lines, in conjunction with biochemical experiments in vitro, indicate that Scc1 phosphorylation is dispensable for cohesin dissociation from chromosomes in early mitosis but enhances the cleavability of SCC1 by separase, and reveals that SA2 is the critical target of Plk1 in the cohesIn dissociation pathway.
View PDF
Cohesin Cleavage by Separase Required for Anaphase and Cytokinesis in Human Cells
TLDR
The results indicate that cohesin cleavage by separase is essential for sister chromatid separation and for the completion of cytokinesis.
View on Publisher
Human Bub1 Defines the Persistent Cohesion Site along the Mitotic Chromosome by Affecting Shugoshin Localization
View on Elsevier
Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres.
TLDR
It is demonstrated that, unlike Sgo1, Sgo2 is dispensable for centromeric protection of cohesin and interacts with Bir1/Survivin and promotes Aurora kinase complex localization to the pericentromeric region, to correct erroneous attachment of kinetochores and enable tension-generating attachment.
View on PubMed
Regulation of Sister Chromatid Cohesion between Chromosome Arms
View on Elsevier
Aurora controls sister kinetochore mono-orientation and homolog bi-orientation in meiosis-I
TLDR
The results provide an explanation for the previously enigmatic observation that fission yeast Shugoshin Sgo2, which assists in loading Aurora to centromeres, and its regulator Bub1 are required for the mono‐orientation of sister chromatids in meiosis‐I.
View on Wiley
Kinetochore Orientation in Mitosis and Meiosis
View on Elsevier
Absolute Proteome and Phosphoproteome Dynamics during the Cell Cycle of Schizosaccharomyces pombe (Fission Yeast)*
TLDR
It is observed that phosphate transporters and phosphate-metabolizing enzymes are phosphorylated and therefore likely to be regulated in mitosis, and 23% of the average intracellular ATP is utilized by protein kinases to phosphorylate their substrates to drive regulatory processes during cell division.
View on Publisher
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License