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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

• Silke Hauf, Richard W. Cole, +7 authors Jan-Michael Peters
• The Journal of cell biology
• 2003

The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small molecule Hesperadin as an inhibitor of… (More)

Two Distinct Pathways Remove Mammalian Cohesin from Chromosome Arms in Prophase and from Centromeres in Anaphase

• Irene C. Waizenegger, Silke Hauf, Andreas Meinke, J. G. Peters
• Cell
• 2000

In yeast, anaphase depends on cohesin cleavage. How anaphase is controlled in vertebrates is unknown because their cohesins dissociate from chromosomes before anaphase. We show that residual amounts… (More)

Dissociation of Cohesin from Chromosome Arms and Loss of Arm Cohesion during Early Mitosis Depends on Phosphorylation of SA2

• Silke Hauf, Elisabeth Roitinger, Birgit Koch, Christina M. Dittrich, Karl Mechtler, Jan-Michael Peters
• PLoS biology
• 2005

Cohesin is a protein complex that is required to hold sister chromatids together. Cleavage of the Scc1 subunit of cohesin by the protease separase releases the complex from chromosomes and thereby… (More)

Human Bub1 Defines the Persistent Cohesion Site along the Mitotic Chromosome by Affecting Shugoshin Localization

• Tomoya S Kitajima, Silke Hauf, Miho Ohsugi, Tadashi Yamamoto, Yoshinori Watanabe
• Current Biology
• 2005

Shugoshin (Sgo) proteins constitute a conserved protein family defined as centromeric protectors of Rec8-containing cohesin complexes in meiosis . In vertebrate mitosis, Scc1/Rad21-containing cohesin… (More)

Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.

• Silke Hauf, Irene C. Waizenegger, Jeffrey M. Peters
• Science
• 2001

Cell division depends on the separation of sister chromatids in anaphase. In yeast, sister separation is initiated by cleavage of cohesin by the protease separase. In vertebrates, most cohesin is… (More)

Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres.

• Shigehiro A. Kawashima, Tatsuya Tsukahara, Maria Langegger, Silke Hauf, Tomoya S Kitajima, Yoshinori Watanabe
• Genes & development
• 2007

Fission yeast shugoshin Sgo1 is meiosis specific and cooperates with protein phosphatase 2A to protect centromeric cohesin at meiosis I. The other shugoshin-like protein Sgo2, which requires the… (More)

Aurora controls sister kinetochore mono-orientation and homolog bi-orientation in meiosis-I

• Silke Hauf, Ashapurno Biswas, Maria Langegger, Shigehiro A. Kawashima, Tatsuya Tsukahara, Yoshinori Watanabe
• The EMBO journal
• 2007

Aurora-B kinases are important regulators of mitotic chromosome segregation, where they are required for the faithful bi-orientation of sister chromatids. In contrast to mitosis, sister chromatids… (More)

Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

• André Koch, Karsten Krug, Stuart Pengelley, Boris Maček, Silke Hauf
• Science signaling
• 2011

Kinases of the Aurora family are essential for the proper execution of mitosis in eukaryotes, and Aurora inhibitors are in clinical trials as anticancer drugs. We applied site-specific quantitative… (More)

Kinetochore Orientation in Mitosis and Meiosis

• Silke Hauf, Yoshinori Watanabe
• Cell
• 2004

Kinetochores are the major point of contact between spindle microtubules and chromosomes. They are assemblies of more than 50 different proteins and take part in regulating and controlling their own… (More)

Regulation of Sister Chromatid Cohesion between Chromosome Arms

• Juan F. Giménez-Abián, Izabela Sumara, +5 authors J. G. Peters
• Current Biology
• 2004

Sister chromatid separation in anaphase depends on the removal of cohesin complexes from chromosomes. In vertebrates, the bulk of cohesin is already removed from chromosome arms during prophase and… (More)

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