Silke Günther

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An implication of 5-HT(2B) receptors in central nervous system has not yet been clearly elucidated. We studied the role of different 5-HT(2) receptor subtypes in the medullary breathing center, the pre-Bötzinger complex, and on hypoglossal motoneurons in rhythmically active transversal slice preparations of neonatal rats and mice. Local microinjection of(More)
Serotonin 5-HT(2B) receptors are often coexpressed with 5-HT(1B) receptors, and cross-talk between the two receptors has been reported in various cell types. However, many mechanistic details underlying 5-HT(1B) and 5-HT(2B) receptor cross-talk have not been elucidated. We hypothesized that 5-HT(2B) and 5-HT(1B) receptors each affect the others' signaling(More)
Although potentially implicated in several physiological functions, few functional mutations have been identified in the human 5-hydroxytryptamine (HT)(2B) receptor gene. A heterozygous mutation R393X in the 5-HT(2B) receptor was recently identified in a patient diagnosed with pulmonary hypertension after intake of the anorexigenic dexfenfluramine. Although(More)
In this paper we present a concept for integrating Multimedia-Enriched Learning Objects (MELOs) within a unifying technological framework for schools. First, we discuss the general role of objects for child development and learning. We then outline the framework architecture of the proposed Networked Environment for Multimedia Objects (NEMO). After-wards,(More)
In this paper we discuss the results of a mobile learning project a young art teacher in training conducted with fifth graders at a local higher secondary school in Germany. In contrast to stationary learning, effectively employed mobile learning technology provides students and teachers with the flexibility and the freedom to reach educational goals while(More)
This paper describes SpelLit, an application, which fosters literacy skills at elementary schools. For the development of our educational software, traditional concepts of learning have been adapted to fit the UniTable, a multi-touch tabletop system for educational purposes, aiming at students of all ages. Multi-touch technology lets users interact in easy(More)
Dieses Paper widmet sich der interdisziplinären Betrachtung eines Kon-zepts zur Integration multimedialer, be-greifbarer Lernobjekte in vernetzte Lern-umgebungen. Mit Hilfe eines auf die Physis bezogenen Schalenmodells werden medienpädagogische,-theoretische,-soziologische und-systemtechnische Überle-gungen zusammengeführt.