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Noonan syndrome (MIM 163950) is characterized by short stature, facial dysmorphism and cardiac defects. Heterozygous mutations in PTPN11, which encodes SHP-2, cause ∼50% of cases of Noonan syndrome. The SHP-2 phosphatase relays signals from activated receptor complexes to downstream effectors, including Ras. We discovered de novo germline KRAS mutations(More)
BACKGROUND Essential thrombocythemia (ET) rarely occurs in the pediatric population and little is known about the clinical course and the molecular characteristics. PROCEDURE In this retrospective multi-institutional study we examine the clinical, hematological, and molecular features of 12 children aged 5-16 years with thrombocytosis and a suspected(More)
disappearance of most and the reduction in size of the remaining splenic lesions, indicating that the splenic abnormalities were secondary to disseminated tuberculosis. The ELISPOT-RD1 detected M. tuberculosis infection, and enabled an early diagnosis of active tuberculosis in our immunosuppressed TST-negative patient in the absence of any other finding(More)
Calcium tartrate crystals were observed in the midgut of grape leafhoppers. This unique compound was found for the first time in insects. The size of the crystals varied strongly between and within individuals with a mean length of 153 ± 87 μm and a mean width of 71 ± 46 μm. In addition, the number of crystals per individual showed a broad variation and(More)
The population dynamics of the grape leafhopper (Empoasca vitis) and its egg parasitoids (Mymaridae) were studied at five representative sites in the Franconian wine-growing region from 1998 to 2001. In contrast to other German wine-growing areas, only one generation of grape leafhoppers per season was observed. In general, irrespective of the application(More)
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