Silja Rott

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Autoimmune diseases like Crohn's disease, rheumatoid arthritis (RA) and psoriasis are often difficult to treat due to complex underlying immunologic pathways. Tumor necrosis factor (TNFalpha) is an important proinflammatory cytokine that seems to play an important role in the pathogenesis of these diseases. After the approval of a variety of drugs which(More)
The group of senior physicians/assistant medical directors between chairman and residents is in a major focus regarding current changes in the medical system in Germany. The manifold clinical tasks clearly underline the importance of senior physicians as key players; they are neither so regarded nor paid accordingly. In addition senior physicians are(More)
Treatment of autoimmune disorders such as psoriasis, rheumatoid arthritis, and Crohn’s disease with so called biologics (selective immunomodulatory drugs) has become a standard way to treat severe or recalcitrant forms of these diseases. In particular, antagonists of tumour necrosis factor (TNF) have been proved to be highly efficacious. In this review we(More)
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