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Inhibition of osteoclast differentiation and bone resorption by rotenone, through down-regulation of RANKL-induced c-Fos and NFATc1 expression.
TLDR
It is suggested that rotenone demonstrated inhibitory effects on osteoclast differentiation in vitro and suppressed inflammatory bone loss in vivo and may therefore serve as a useful drug in the prevention of bone loss. Expand
GM-CSF Regulates Fusion of Mononuclear Osteoclasts into Bone-Resorbing Osteoclasts by Activating the Ras/ERK Pathway1
TLDR
It is demonstrated that GM-CSF induced fusion of pOCs to form multinucleated osteoclasts, making the osteoclast capable of bone resorption. Expand
PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings
TLDR
It is reported that recently developed p21-activated kinase 4 inhibitor PF-3758309 shows anti-metastatic effect in A549 human lung cancer cell and suppresses CREB, NF-κB, and β-catenin pathways, which are well known to be closely related with cell migration. Expand
Anti-osteoclastogenic activity of matairesinol via suppression of p38/ERK-NFATc1 signaling axis
TLDR
Matairesinol dose-dependently inhibited the RANKL-induced differentiation of BMMs into osteoclasts by downregulating RANKC1-induced expression and activity of NFATc1, suggesting that the anti-osteoclastogenic activity of mataires inol could arise from its anti-OSTeoporotic potential via p38/ERK-NFatc1 signaling, but not by way of anti-resorptive action. Expand
Inhibitory regulation of osteoclast differentiation by interleukin‐3 via regulation of c‐Fos and Id protein expression
TLDR
The results suggest that IL‐3 plays an inhibitory role in osteoclast differentiation by regulating c‐Fos and Ids, and also exerts anti‐bone erosion effects. Expand
Anti-Osteoclastogenic Activity of Praeruptorin A via Inhibition of p38/Akt-c-Fos-NFATc1 Signaling and PLCγ-Independent Ca2+ Oscillation
TLDR
Paeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Expand
Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation
TLDR
It is suggested that Bacillus-fermented antler extract could inhibit PLCγ2-NFATc1 signaling required for bone resorption and cell fusion, which might benefit osteoclast-related disorders, including osteoporosis; furthermore, it may improve gastrointestinal activity. Expand
Arginase 1 is a negative regulator of osteoclast differentiation
TLDR
It is concluded that Arg1 is down-regulated during osteoclast differentiation and may negatively regulate osteoc Last differentiation by regulating NO production, and Arg1 and NO have reciprocal roles as negative and positive regulators, respectively, of osteOClast differentiation. Expand
Osteoporotic bone of miR-150-deficient mice: Possibly due to low serum OPG-mediated osteoclast activation
TLDR
Down-regulation of miR-150 is observed during in vitro osteoclast differentiation and, furthermore, that miR150 knockout mice exhibit decreased bone mass and an increased number of osteoclasts. Expand
Anti-cancer activity of ZnO chips by sustained zinc ion release
TLDR
Molecular analysis of cells treated with ZnO chips revealed that zinc ions released from the chips increased cellular levels of reactive oxygen species, including hydrogen peroxide, which led to the down-regulation of anti-apoptotic molecules and caspase-dependent apoptosis. Expand
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