Sigurdur Stefansson

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Rous sarcoma virus-transformed cultures of chicken embryo fibroblasts (RSVCEF) secrete elevated levels of a 70 kDa progelatinase, an avian form of the 72 kDa matrix metalloproteinase-2 (MMP-2). Affinity-purified preparations of secreted 70 kDa progelatinase are composed of two distinct populations of zymogen: a 70 kDa progelatinase tightly complexed with an(More)
Optokinetic nystagmus (OKN) and nystagmus induced by the rotational test were analyzed in sixty normal subjects, 13 to 68 years old. Reactivity was measured by the maximum slow phase velocity. A slight linear correlation to age was found in both tests. In the OKN test the eye speed increased with advancing age, and in the rotational test the eye speed(More)
This study was designed to investigate the incidence and clinical consequences of hemidiaphragmatic paresis in patients undergoing carotid endarterectomy using cervical plexus block anesthesia. In 28 patients, diaphragmatic motion was evaluated by fluoroscopy 20 min after cervical plexus block with 1% mepivacaine. In 61% of the patients abnormalities of(More)
BACKGROUND Tolerance to nitrovasodilators, including sodium nitroprusside (SNP), is a clinical problem. SNP causes vasodilatation by releasing nitric oxide, which stimulates intracellular guanosine 3':5'-cyclic monophosphate (cGMP) accumulation in smooth muscle cells. This study examined tolerance to SNP in coronary smooth muscle cells by measuring(More)
In a double-blind study cefixime, an oral cephalosporin of the third generation, was compared to cefaclor in the treatment of acute otitis media in 397 children aged 6 months to 12 years. Clinical evaluation was carried out at the beginning, at day 10-12 and day 28-35 after the start of the treatment. Specimens for bacterial culture and sensitivity testings(More)
Previous research in neuroendocrinology has evidenced that hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA) depends on hypersecretion of corticotropin-releasing hormone (CRH). The aim of this study was to investigate the activity of HPA before and after recovery in depressed patients treated with electroconvulsive therapy (ECT). An(More)
UNLABELLED Superior canal dehiscence is a rare syndrome. The symptoms consist of hearing loss, dizziness and autophonia. The patient can be cured with surgery. A 28 year old woman went to several doctors for several months due to diminished hearing, dizziness and autophonia. The symptoms got worse. A work-up led to the diagnosis of superior canal dehiscence(More)
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