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Brassinosteroids (BRs) are steroid hormones that are essential for the development of plants. A tight control of BR homeostasis is vital for modulating their impact on growth responses. Although it is recognized that the rapid adaptation of de novo synthesis has a key role in adjusting required BR levels, our knowledge of the mechanisms governing feedback(More)
BACKGROUND Brassinosteroids (BRs) are signaling molecules that play essential roles in the spatial regulation of plant growth and development. In contrast to other plant hormones BRs act locally, close to the sites of their synthesis, and thus homeostatic mechanisms must operate at the cellular level to equilibrate BR concentrations. Whilst it is recognized(More)
Brassinosteroids (BRs) are plant steroid hormones with structural similarity to mammalian sex steroids and ecdysteroids from insects. The BRs are synthesized from sterols and are essential regulators of cell division, cell elongation and cell differentiation. In this work we show that voriconazole, an antifungal therapeutic drug used in human and veterinary(More)
1 Brassinosteroid-regulated GSK3/shaggy-like kinases phosphorylate MAP kinase kinases, which control stomata development in Arabidopsis thaliana Background: Brassinosteroids (BRs) are plant steroids, which signal through the inhibition of GSK3/shaggy-like kinases such as BIN2. Results: We here show that BIN2 phosphorylates MKK4, which inhibits its activity(More)
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