Sigmund J. Kharasch

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HIV postexposure prophylaxis (PEP) is now a well-established part of the management of health care workers after occupational exposures to HIV. Use of PEP for adults exposed to HIV after sexual contact or injection drug use in nonoccupational settings remains controversial with limited data available. There is even less information available concerning HIV(More)
BACKGROUND Nonoccupational human immunodeficiency virus (HIV) postexposure prophylaxis (PEP) for adults has been described, although the Centers for Disease Control and Prevention, Atlanta, Ga, offer no specific recommendations. There is limited information about its use in children and adolescents. OBJECTIVE To describe the current practices of(More)
Pneumocephalus or air within the cranial vault is usually associated with disruption of the skull caused by head trauma, neoplasms, or after craniofacial surgical interventions. We report a child who presented with headache and the pathognomonic "succussion splash" and was found to have atraumatic pneumocephalus from forceful valsalva maneuvers.(More)
STUDY OBJECTIVE To evaluate the usefulness of routine radiographs and arterial blood gases in children with blunt trauma. DESIGN Retrospective chart review. TYPE OF PARTICIPANTS Ninety patients who met triage criteria for our trauma team evaluation and who were less than 15 years old were evaluated. Patients with a Glasgow Coma Scale score (GCS) of 15(More)
OBJECTIVE The purpose of this prospective, randomized, single-blind trial was to assess the clinical efficacy of a single intramuscular dose of ceftriaxone compared with 10 days of oral trimethoprim-sulfamethoxazole (TMP-SMZ) in treating acute otitis media (AOM). METHODS Children aged 3 months through 3 years diagnosed with AOM (signs of acute illness(More)
OBJECTIVES To measure the prevalence of gonorrhea, chlamydia, and human immunodeficiency virus (HIV) infection among emergency department (ED) patients who accept screening, and to assess treatment outcomes and risks for infection. METHODS Research staff offered voluntary testing for gonorrhea and chlamydia (by urine transcription-mediated amplification)(More)
CONTEXT Violence-related injuries among children are common, but age-based incidence data are not easily available. OBJECTIVES To describe injuries due to violence in a population-based case series of children and to estimate injury incidence. DESIGN Prospective surveillance of children residing in Boston, Mass, who received pediatric emergency(More)
OBJECTIVE To determine the prevalence of cocaine exposure among preschool children with clinically unsuspected signs and/or symptoms. DESIGN Prevalence study. SETTING Pediatric emergency department in an inner-city hospital. PARTICIPANTS 250 children aged 2 weeks to 5 years who underwent urine assays for cocaine prior to discharge from the emergency(More)
OBJECTIVE Adherence to current guidelines for treatment of non-complicated community-acquired pneumonia (CAP) in children, recommending penicillin or ampicillin as first-line treatment, has been poor. Our objective was to examine whether cefuroxime confers an advantage over penicillin or ampicillin for the treatment of children hospitalized with(More)