Siegfried Wagner

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Prostate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest. The commonly performed screening of the prostate-specific antigen (PSA) is controversially discussed, as in many patients the prostate-specific antigen levels are chronically elevated in the absence(More)
The discovery of the post-transcriptional gene silencing (PTGS) by small non-protein-coding RNAs is considered as a major breakthrough in biology. In the last decade we just started to realize the biologic function and complexity of gene regulation by small non-coding RNAs. PTGS is a conserved phenomenon which was observed in various species such as fungi,(More)
Direct Numerical Simulations of laminar separation bubbles are presented. The bubbles are generated by prescribing a locally decelerated free-stream velocity along a at-plate. Controlled disturbances are introduced into the ow eld upstream of the bubble by suction and blowing through the wall in order to study the linear and nonlinear stability c(More)
Laminar-turbulenttransition mechanisms induced by a harmonic point source disturbance in a at-plate boundary layer with adverse pressure gradient are investigated by fourth-order accurate spatial direct numerical simulation based on the complete three-dimensional Navier–Stokes equations for incompressible ow. The disturbance is introduced into the(More)
The main outcome of this work is elaboration of classification models for edible oil samples representing the most widespread brands of Austrian pumpkin seed oil. A complete spectral characterisation of the pumpkin seed oil samples by UV-Vis, NIR and FTIR spectra was obtained together with their basic sensorial classification. Chemometrical processing of(More)
The unsteady Navier{Stokes equations ooer a large variety of instantaneous solutions even for rather simple boundary conditions once the relevant spatial and temporal scales of the problem at hand are adequately resolved. This is especially true for DNS (Direct Numerical Simulation) of laminar-turbulent transition, where an initially lam-inar ow, disturbed(More)
BACKGROUND In molecular medicine, the manipulation of cells is prerequisite to evaluate genes as therapeutic targets or to transfect cells to develop cell therapeutic strategies. To achieve these purposes it is essential that given transfection techniques are capable of handling high cell numbers in reasonable time spans. To fulfill this demand, an(More)
Cell lines are key tools in cancer research allowing the generation of neoplasias in animal models resembling the initial tumours able to mimic the original neoplasias closely in vivo. Canine lymphoma is the major hematopoietic malignancy in dogs and considered as a valuable spontaneous large animal model for human Non-Hodgkin's Lymphoma (NHL). Herein we(More)
Ultrashort pulsed laser ablation in liquids represents a powerful tool for the generation of pure gold nanoparticles (AuNPs) avoiding chemical precursors and thereby making them especially interesting for biomedical applications. However, because of their electron accepting properties, laser-generated AuNPs might affect biochemical properties of(More)