Siegfried Knasmuller

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Over the last 30 years approximately 160 reports have been published on dietary compounds that protect from the mutagenic and carcinogenic effects of heterocyclic aromatic amines (HAAs). In the first section of this review, the current state of knowledge is briefly summarized. Based on the evaluation of the available data, various protective mechanisms are(More)
Glutathione (GSH) is an important antioxidant and cofactor of detoxifying metabolism. Therefore, elevation of GSH as achieved by inducing g-glutamylcysteine synthetase (GCS), the limiting enzyme of GSH synthesis, may contribute to chemoprevention against cancer. In previous animal studies, increases in GCS were mainly found in liver and other organs that(More)
A rapid differential DNA-repair assay procedure was developed to investigate the biotransformation of xenobiotics in Drosophila melanogaster in vivo. Indicator of genotoxic activity was a pair of streptomycin-dependent Escherichia coli strains differing vastly in DNA repair capacity (uvr+/rec+ vs. uvrB/recA). Prior to the experiments with test compounds,(More)
Tannic acid (TA), a complex mixture of polyphenolics, exhibited synergism with 4-nitroquinoline 1-oxide (4-NQO), methyl methanesulfonate (MMS) and cis-platinum (cis-DDP) in a recent study on w/w+ somatic mutation in the eye pigment of Drosophila, although several studies indicated that tannic acid is an antimutagen in cultured mammalian cells. The goal of(More)
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