Siegfried J. Schmidt

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Irritable bowel syndrome (IBS) is a common intestinal ailment of which the pathophysiological mechanisms are not well understood. Most IBS patients demonstrate enhanced perception, visceral hypersensitivity, in response to distension of the gut lumen but there are conflicting results about changes in somatic sensitivity. This study focused on the possible(More)
The role of the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene in the genesis of diabetic nephropathy has been controversial. It has recently been proposed that progression occurs more rapidly in individuals with diabetic and non-diabetic renal disease who are homozygous for the D allele. We studied 658 patients with type II(More)
OBJECTIVES To describe and understand varieties and characteristics of sensitization contributing to hyperalgesia in participants with chronic pain conditions. METHODS Thermal stimulation was delivered to the face, forearm, and calf of pain-free participants and individuals with irritable bowel syndrome, temporomandibular pain disorder (TMD), and(More)
This study evaluated relationships between irritable bowel syndrome (IBS) pain, sympathetic dysregulation, and thermal pain sensitivity. Eight female patients with diarrhea-predominant IBS and ten healthy female controls were tested for sensitivity to thermal stimulation of the left palm. A new method of response-dependent thermal stimulation was used to(More)
During the course of a psychophysical study of fibromyalgia syndrome (FMS), one of the subjects with a long history of headache and facial pain displayed an extraordinarily severe thermal allodynia. Her stimulus-response function for ratings of cutaneous heat pain revealed a sensitivity clearly beyond that of normal controls and most FMS subjects. Specially(More)
Generalized hypersensitivity that extends into somatic areas is common in patients with irritable bowel syndrome (IBS). The sensitized state, particularly assessed by experimental methods, is known to persist even during remissions of clinical pain. It was hypothesized that disease-related nociceptive activity in the gut maintains a systemic-sensitized(More)
3. Bernardin A et al. VYCROSS™: An innovative dermal filler technology; Posterpräsentation beim AMEC 2013. The science and art of dermal fillers for soft-tissue augmentation. A prospective, observational study of the volumizing effect of open-label aesthetic use of Juvéderm(®) VOLUMA(®) with Lidocaine in mid-face area.
Over the last decades Heinz von Foerster has brought the observer from behind the stages to the central stage of epistemological issues and discussions. This article discusses the multiple dimensions of observers and the consequences of a fully-developed observer story for the status of scientific knowledge and for the social system of science in general.(More)
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