Sidney Weinhouse

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In previous publications we reported that oxidative processes of the citric acid cycle in tumor homogenates (29) or mitochondria isolated there from (30) are limited by the loss of diphosphopyridine nucleotide activity and that oxygen consump tion can be restored by the addition of this coenzyme to the medium in relatively high concen tration. The present(More)
  • S. Weinhouse
  • Zeitschrift für Krebsforschung und Klinische…
  • 1976
It is just about 50 years ago that Otto Warburg announced his famous theory of respiratory impairment in cancer (Warburg; 1926). Proposed and defended with evangelical fervor, it so captured the imagination of scientists that even today it serves for many as a guiding principle for the understanding if not the cure of cancer. It is natural for people, even(More)
Recent studies from our laboratory have disclosed that rat liver contains a glucose-adenosine triphosphate phosphotransferase which differs from the hitherto described conventional hexokinases in having a low aflinity for glucose, with a K, of 0.01 to 0.02 M (1). The activity of this enzyme falls to low levels in fasting and alloxan diabetes (2), and its(More)
It is now clearly established that insulin controls the utilization of glucose by muscle and adipose tissue (l-4), presumably by stimulating glucose transport across an otherwise impermeable cell membrane. Although a similar role of insulin in hepatic glucose uptake seems unlikely, since the liver cell is reported to be freely permeable to both inflow and(More)